Atogepant Impurity 18 CAS CATO-C4X-328518
| CAS No. | CATO-C4X-328518 |
| Molecular Formula | C21H28F3NO5 |
| Molecular Weight | 431.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Atogepant Impurity 18 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Atogepant Impurity 18 (CAS CATO-C4X-328518, C21H28F3NO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Atogepant Impurity 18 (C21H28F3NO5) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C21H28F3NO5 |
| Molecular Weight | 431.45 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Atogepant Standards
- Atogepant Impurity 22 (CAS 1318253-26-7)
- Atogepant Impurity 17 (CAS CATO-C4X-328517)
- Atogepant Impurity 21 (CAS 1375542-65-6)
- Atogepant Impurity 33 (CAS 1375471-12-7)
- Atogepant Impurity 52 (CAS CATO-C4X-328552)
- Atogepant Impurity 53 (CAS 1456803-44-3)
- Atogepant Impurity 54 (CAS CATO-C4X-328554)
- Atogepant Impurity 55 (CAS CATO-C4X-328555)
Recommended Standards
- 2,6-Dimethylphenyl 2-[N-(2,4-difluorophenyl)benzenesulfonamido]acetate (CAS 343373-97-7)
- BOc-l-lys(ns)-oh (CAS 1301706-36-4)
- Rimsulfuron (CAS 122931-48-0)
- 2-(4-Acetamido-3-methoxybenzenesulfonamido)-3-(1h-indol-3-yl)propanoic acid (CAS 1396966-98-5)
- Sivelestat Impurity 10 (CAS CATO-C4X-212310)
- Epinephrine /Adrenaline Impurity 131 (CAS CATO-C4X-1849131)
- Valsartan EP Impurity A (CAS 137862-87-4)
- (S)-tert-Butyl ethyl((1-(2-hydroxyethyl)pyrrolidin-2-yl)methyl)carbamate (CAS 1354003-23-8)
- 3,3-dimethoxycyclobutanecarboxamide (CAS 2360931-42-4)
- 2-(2-Hydroxypropan-2-yl)thiazole-5-sulfonamide (CAS 2143028-32-2)
- (R)-1,5-diethylpiperazin-2-one (CAS 1217603-45-6)
- Manganese antimonide(2:1) (CAS 12032-97-2)
- Ethyl 2-methyl-2-(methylamino)propanoate (CAS 58743-30-9)
- Peptide YY (human) trifluoroacetate salt (CAS 118997-30-1)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com