Capivasertib Impurity 8 CAS CATO-C4X-33128
| CAS No. | CATO-C4X-33128 |
| Molecular Formula | C23H29ClN6O2 |
| Molecular Weight | 456.97 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Capivasertib Impurity 8 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Capivasertib Impurity 8 (CAS CATO-C4X-33128, C23H29ClN6O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Capivasertib Impurity 8 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 456.97 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Capivasertib Impurity 8 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H29ClN6O2 |
| Molecular Weight | 456.97 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Capivasertib Standards
- Capivasertib Impurity 31 (CAS CATO-C4X-331231)
- Capivasertib Impurity 36 (CAS CATO-C4X-331236)
- Capivasertib Impurity 11 (CAS CATO-C4X-331211)
- Capivasertib Impurity 7 (CAS CATO-C4X-33127)
- Capivasertib Impurity 12 (CAS CATO-C4X-331212)
- Capivasertib Impurity 29 (CAS CATO-C4X-331229)
- Capivasertib Impurity 35 (CAS CATO-C4X-331235)
- Capivasertib-D4 (CAS CATO-C4X-331214)
Recommended Standards
- (E)-N-[2-[[[3-(4-Chlorophenyl)allyl](methyl)amino]methyl]phenyl]-4-methoxybenzenesulfonamide (CAS 1283519-40-3)
- Enarodustat Impurity 33 (CAS CATO-C4X-322833)
- 4-(4-(3-Chlorophenyl)-4-(pyrrolidine-1-carbonyl)piperidin-1-yl)-1-(4-fluorophenyl)butan-1-one (CAS 2924-46-1)
- Enarodustat Impurity 32 (CAS CATO-C4X-322832)
- Milrinone Impurity 29 (CAS CATO-C4X-109129)
- Methimazole impurity 7 (CAS CATO-C4X-20607)
- Landiolol Impurity 53 (CAS 64704-12-7)
- 1-(4-Bromo-2-nitrophenyl)-1,4-diazepane (CAS 1016837-21-0)
- 4-Acetyl-2-fluorobenzonitrile (CAS 214760-18-6)
- 2-Bromo-4-(bromomethyl)pyridine hydrobromide (CAS 32938-44-6)
- 6-Methyl-2-((4-methylbenzyl)thio)pyrimidin-4-ol (CAS 329226-32-6)
- 6-(Trifluoromethyl)-2H-pyrazolo[4,3-b]pyridine (CAS 1822712-61-7)
- 4-bromophenoxymethanecarbothioyl chloride (CAS 10506-24-8)
- Gastric Inhibitory Polypeptide (human) (CAS 100040-31-1)
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