Capivasertib Impurity 35 CAS CATO-C4X-331235
| CAS No. | CATO-C4X-331235 |
| Molecular Formula | C22H25ClN6O4 |
| Molecular Weight | 472.92 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Capivasertib Impurity 35 (CAS CATO-C4X-331235) is a certified pharmaceutical impurity reference standard with the molecular formula C22H25ClN6O4 and a molecular weight of 472.92 g/mol.
The molecular framework of Capivasertib Impurity 35 (C22H25ClN6O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H25ClN6O4 |
| Molecular Weight | 472.92 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Capivasertib Standards
- Capivasertib Impurity 29 (CAS CATO-C4X-331229)
- Capivasertib Impurity 36 (CAS CATO-C4X-331236)
- Capivasertib Impurity 3 (CAS CATO-C4X-33123)
- Capivasertib Impurity 4 (CAS CATO-C4X-33124)
- Capivasertib Impurity 31 (CAS CATO-C4X-331231)
- Capivasertib Impurity 8 (CAS CATO-C4X-33128)
- Capivasertib Impurity 34 (CAS CATO-C4X-331234)
- Capivasertib Impurity 11 (CAS CATO-C4X-331211)
Recommended Standards
- (S)-tert-Butyl 2-((4-chloro-2-fluoro-5-((3-phenylprop-2-yn-1-yl)oxy)phenyl)carbamoyl)pyrrolidine-1-carboxylate (CAS 1464137-29-8)
- N-(4-Chloro-3-methyl-1,2-oxazol-5-yl)-4-methoxy-N-(4-methoxybenzenesulfonyl)benzene-1-sulfonamide (CAS 478262-44-1)
- 3-((4-Chlorophenyl)sulfonyl)-2-imino-1-(3-methoxypropyl)-10-methyl-1H-dipyrido[1,2-a:2',3'-d]pyrimidin-5(2H)-one (CAS 606961-13-1)
- methyl (1R,3S)-1-(1-(tert-butoxycarbonyl)-5-chloro-1H-indol-3-yl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (CAS 1395347-28-0)
- Lefamulinum Impurity (CAS CATO-C4X-304728)
- Capivasertib Impurity 21 (CAS CATO-C4X-331221)
- Belumosudil Impurity 68 (CAS CATO-C4X-298868)
- 5-Amino-6,7,8,9-tetrahydro-5h-benzo[7]annulene-5-carboxylic acid (CAS 889941-69-9)
- N-Isopentyl-2-(2-((4-methylbenzyl)thio)thiazol-4-yl)acetamide (CAS 941984-77-6)
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- 1-(Prop-2-enoyl)pyrrolidine-2-carboxylic acid (CAS 1391948-29-0)
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