Nefazodone Impurity 1 CAS CATO-C4X-33501
| CAS No. | CATO-C4X-33501 |
| Molecular Formula | C25H32ClN5O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Nefazodone Impurity 1.
Nefazodone Impurity 1 (CAS CATO-C4X-33501) is a certified pharmaceutical impurity reference standard with the molecular formula C25H32ClN5O2HCl and a molecular weight of 506.47 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Nefazodone Impurity 1 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 506.47 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Nefazodone Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H32ClN5O2 HCl |
| Molecular Weight | 506.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Nefazodone Standards
- Nefazodone Related Compound A (25 mg) (1-(3-chlorophenyl)-4-(3-chloropropyl)-piperazine hydrochloride) (CAS 57059-62-8)
- Nefazodone Hydrochloride (CAS 82752-99-6)
- Nefazodone (CAS 83366-66-9)
- Nefazodone Impurity 5 (CAS 95885-13-5)
- Nefazodone Impurity 6 (CAS 98159-82-1)
- Nefazodone Impurity 9 (CAS 98159-88-7)
Recommended Standards
- Empagliflozin Impurity 17 (CAS CATO-C4X-106517)
- Clopidogrel Impurity 63 (CAS CATO-C4X-102963)
- Daptomycin Impurity 5 (CAS CATO-C4X-13785)
- 5-(Benzyloxy)-2-methylbenzaldehyde (CAS 1450931-38-0)
- 4-Amino-5-(difluoromethyl)-6-methylpicolinic acid (CAS 1805221-21-9)
- N-(2,3-dihydro-1H-inden-5-yl)thietan-3-amine (CAS 1881180-73-9)
- 3-(Piperidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS 1402166-10-2)
- Ethyl 4-methanesulfonylcinnamate (CAS 137473-27-9)
- 8-Chloroquinoline-4-carboxylic acid (CAS 121490-66-2)
- Galanin-Like Peptide (porcine) trifluoroacetate salt (CAS 245114-96-9)
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