Icariin Impurity 1 CAS CATO-C4X-33511

Purity 97%+In StockPharmacopoeial Impurity Standards
CAS No.CATO-C4X-33511
Molecular FormulaC21H20O6
Molecular Weight368.38 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Icariin Impurity 1 CAS CATO-C4X-33511 chemical structure

Description

CATO supplies Icariin Impurity 1 (CAS CATO-C4X-33511), a pharmacopoeial impurity reference standard (molecular formula C21H20O6, MW 368.38 g/mol) used for the identification and quantification of trace impurities in APIs.

Icariin Impurity 1 (C21H20O6) contains a flavonoid core, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC21H20O6
Molecular Weight368.38 g/mol
AppearancePale yellow to yellow crystalline powder
Purity97%+
StorageStore at 2-8°C, protect from light, keep sealed and dry
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)12.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present

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