Tivozanib Impurity 20 CAS CATO-C4X-340020
| CAS No. | CATO-C4X-340020 |
| Molecular Formula | C22H19ClN4O6 |
| Molecular Weight | 470.86 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Tivozanib Impurity 20 (CAS CATO-C4X-340020, C22H19ClN4O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C22H19ClN4O6, Tivozanib Impurity 20 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 470.86 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Tivozanib Impurity 20 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H19ClN4O6 |
| Molecular Weight | 470.86 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Tivozanib Standards
- Tivozanib Impurity 10 (CAS CATO-C4X-340010)
- Tivozanib D6 (CAS CATO-C4X-34001)
- Tivozanib Impurity 13 (CAS CATO-C4X-340013)
- Tivozanib (CAS 475108-18-0)
- Tivozanib Impurity 12 (CAS CATO-C4X-340012)
- Tivozanib Impurity 18 (CAS CATO-C4X-340018)
- Tivozanib Impurity 14 (CAS CATO-C4X-340014)
- Tivozanib Impurity 8 (CAS CATO-C4X-34008)
Recommended Standards
- 4-(4-(4-(2-Chloro-4-nitrophenyl)piperazine-1-carbonyl)-5-methylisoxazol-3-yl)benzoic acid (CAS 1415559-66-8)
- 3-(2-chloro-6-fluorobenzyl)-7-[(dimethoxyphosphorothioyl)oxy]-4-propyl-2H-chromen-2-one (CAS 680214-79-3)
- N-(3,5-Bis(trifluoromethyl)phenyl)-2-((5-chlorobenzo[d]thiazol-2-yl)thio)acetamide (CAS 399009-85-9)
- 6-Chloro-3-(2-((2-(5-fluoro-1H-indol-3-yl)ethyl)amino)-2-oxoethyl)-4-methyl-2-oxo-2H-chromen-7-yl acetate (CAS 903856-14-4)
- Fludarabine Phosphate EP Impurity A (CAS 62314-92-5)
- Amlodipine Impurity 89 (CAS CATO-C4X-109589)
- Finerenone Impurity 228 (CAS CATO-C4X-2880228)
- (S)-tert-Butyl (2-(methylamino)propyl)carbamate (CAS 454709-95-6)
- Peritassine A (CAS 262601-67-2)
- 2-(Benzo[d][1,3]dioxol-5-yl)piperidine (CAS 383128-51-6)
- (S)-N,N-Bis(2-(trifluoromethyl)benzyl)pyrrolidin-3-amine (CAS 820983-85-5)
- 4-Hydroxy-3-((4-methylpiperidin-1-yl)methyl)benzoic acid (CAS 1707378-77-5)
- TETRAHYDROLINALYL ACETATE (CAS 20780-48-7)
- Semaglutide impurity 277 (CAS CATO-C4X-2226277)
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