Safinamide Impurity 37 CAS 1000370-27-3
| CAS No. | 1000370-27-3 |
| Molecular Formula | C24H24F2N2O2 |
| Molecular Weight | 410.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Safinamide Impurity 37.
As a process- or degradation-related impurity, Safinamide Impurity 37 (CAS 1000370-27-3, C24H24F2N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C24H24F2N2O2, Safinamide Impurity 37 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 410.46 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H24F2N2O2 |
| Molecular Weight | 410.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Safinamide Standards
- Safinamide Impurity 47 (CAS 1000370-28-4)
- Safinamide impurity 52 (CAS 100370-27-3)
- Safinamide Impurity 36 (CAS CATO-C4X-159011)
- Safinamide Impurity 60 (CAS CATO-C4X-159060)
- Safinamide Impurity 66 (CAS CATO-C4X-159066)
- Safinamide Impurity 30 (CAS CATO-C4X-159030)
- Safinamide Impurity 57 (CAS CATO-C4X-159057)
- Safinamide Impurity 58 (CAS CATO-C4X-159058)
Recommended Standards
- Pteroside D (CAS 35943-38-5)
- Pteroside A (CAS 35910-15-7)
- Onitin 2'-O-glucoside (CAS 76947-60-9)
- Melphalan Impurity 29 (CAS CATO-C4X-198829)
- Budesonide impurity 42 (CAS CATO-C4X-138942)
- Ivabradine impurity 75 (CAS CATO-C4X-111975)
- Olaparib Impurity N14 (CAS 1983186-05-5)
- 4-(3-Bromo-4-fluorophenoxy)benzenesulfonamide (CAS 1551728-64-3)
- (Z)-3,4-Dichloro-N-(morpholino(phenyl)methylene)aniline (CAS 1164462-93-4)
- 2-Acetyl-4-Boc-morpholine (CAS 1228600-46-1)
- 2-Bromo-5-(difluoromethyl)-3-methyl-4-nitropyridine (CAS 1807022-78-1)
- 5-Methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carboxylic acid (CAS 876379-81-6)
- Methyl 2-(4-(aminomethyl)-2-fluorophenyl)acetate (CAS 2170478-31-4)
- Semaglutide impurity 32 (CAS CATO-C4X-222632)
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