Tadalafil Impurity 10 CAS 100077-49-4
| CAS No. | 100077-49-4 |
| Molecular Formula | C9H8O4 |
| Molecular Weight | 180.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Tadalafil Impurity 10 (CAS 100077-49-4, C9H8O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C9H8O4, Tadalafil Impurity 10 contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 180.16 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H8O4 |
| Molecular Weight | 180.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
Related Tadalafil Standards
- Tadalafil Impurity 136 (CAS 52302-45-1)
- Tadalafil Impurity 137 (CAS 859964-45-7)
- Tadalafil Impurity 53 (CAS 23170-77-6)
- Tadalafil Impurity 135 (CAS CATO-C4X-1087135)
- Tadalafil Impurity 101 (CAS 20850-43-5)
- Tadalafil Impurity 99 (CAS 114152-23-7)
- Tadalafil Impurity 118 (CAS CATO-C4X-1087118)
- Tadalafil Impurity 132 (CAS CATO-C4X-1087132)
Recommended Standards
- methyl 5,5-difluorooxane-3-carboxylate (CAS 2306261-85-6)
- 4-(4-Nitro-1h-pyrazol-1-yl)butanenitrile (CAS 1006572-00-4)
- Methyl 3,3-difluoro-1-(hydroxymethyl)cyclobutanecarboxylate (CAS 2503204-82-6)
- D-GLUCOSE 13C (CAS 101615-88-7)
- Lovastatin Impurity 17 (CAS CATO-C4X-168417)
- Linagliptin Impurity 84 (CAS 6972-78-7)
- Lenvatinib Impurity 119 (CAS CATO-C4X-1140119)
- 4-[(4-Fluorophenyl)methyl]-2,3,4,5-tetrahydro-1,4-benzoxazepin-5-one (CAS 866156-34-5)
- 2-((5-(4-Chlorophenyl)-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)-N-(2,6-dimethylphenyl)acetamide (CAS 477332-70-0)
- (3R,6R)-6-Methylpiperidin-3-ol (CAS 285995-17-7)
- (S)-Ethyl 2-amino-3-(2-chlorophenyl)-2-methylpropanoate (CAS 1241681-72-0)
- N-(5-Isopropyl-1H-1,2,4-triazol-3-yl)-2-methylpropanamide (CAS 1160264-38-9)
- (7-Carboxyheptyl)triphenylphosphonium bromide (CAS 52956-93-1)
- Hexapeptide-11 (CAS 161258-30-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com