Tadalafil Impurity 137 CAS 859964-45-7
| CAS No. | 859964-45-7 |
| Molecular Formula | C9H6O4 |
| Molecular Weight | 178.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Tadalafil Impurity 137 (CAS 859964-45-7) is a certified pharmaceutical impurity reference standard with the molecular formula C9H6O4 and a molecular weight of 178.14 g/mol.
The molecular framework of Tadalafil Impurity 137 (C9H6O4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C9H6O4 |
| Molecular Weight | 178.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
Related Tadalafil Standards
- Tadalafil Impurity 136 (CAS 52302-45-1)
- Tadalafil Impurity 53 (CAS 23170-77-6)
- Tadalafil Impurity 10 (CAS 100077-49-4)
- Tadalafil Impurity 101 (CAS 20850-43-5)
- Tadalafil Impurity 135 (CAS CATO-C4X-1087135)
- Tadalafil Impurity 99 (CAS 114152-23-7)
- Tadalafil Impurity 106 (CAS 23126-68-3)
- Tadalafil Impurity 118 (CAS CATO-C4X-1087118)
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