Doxapram EP Impurity B HCl CAS 100106-91-0
| CAS No. | 100106-91-0 |
| Molecular Formula | C22H28N2O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Doxapram EP Impurity B HCl (C22H28N2O2HCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Doxapram EP Impurity B HCl (CAS 100106-91-0) is a certified pharmaceutical impurity reference standard with the molecular formula C22H28N2O2HCl and a molecular weight of 388.94 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H28N2O2 HCl |
| Molecular Weight | 388.94 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Doxapram Standards
- Doxapram hydrochloride (CAS 113-07-5)
- Doxapram Impurity 3 (CAS 117-34-0)
- Doxapram Impurity 31 (CAS 1415394-56-7)
- Doxapram Impurity 21 (CAS 14327-53-8)
- Doxapram Impurity 19 (CAS 14563-97-4)
- Doxapram EP Impurity B (CAS 1688-76-2)
- Doxapram impurity 42 (CAS 1700553-99-6)
- Doxapram impurity 39 (CAS 2156014-06-9)
Recommended Standards
- Diltiazem Impurity 20 (CAS 132830-16-1)
- Orforglipron impurity 78 (CAS CATO-C4X-323478)
- Pemafibrate Impurity 85 (CAS CATO-C4X-290385)
- (1-(4-Fluorophenyl)pyrrolidin-3-yl)methanamine hydrochloride (CAS 1269054-41-2)
- (2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-5-oxo-5-prop-2-enoxypentanoic acid (CAS 259221-91-5)
- (3-Aminopiperidin-1-yl)(2-(1-ethyl-1H-indol-2-yl)-1-methyl-1H-benzo[d]imidazol-6-yl)methanone hydrochloride (CAS 1652591-82-6)
- 6-Chloro-3-(difluoromethyl)-5-nitropyridin-2-ol (CAS 1806872-35-4)
- endo-tert-Butyl 3-azabicyclo[3.1.1]heptan-6-ylcarbamate (CAS 1614256-81-3)
- Methyl 2-(4-hydroxypyrimidin-2-yl)acetate (CAS 66621-49-6)
- Exenatide (CAS 141758-74-9（free base）)
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