Doxapram EP Impurity B CAS 1688-76-2
| CAS No. | 1688-76-2 |
| Molecular Formula | C22H28N2O2 |
| Molecular Weight | 352.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Doxapram EP Impurity B (CAS 1688-76-2), a pharmacopoeial impurity reference standard (molecular formula C22H28N2O2, MW 352.47 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Doxapram EP Impurity B (C22H28N2O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), Doxapram EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H28N2O2 |
| Molecular Weight | 352.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 2 |
Related Doxapram Standards
- Doxapram Impurity 30 (CAS CATO-C4X-197330)
- Doxapram Impurity 44 (CAS CATO-C4X-197344)
- Doxapram Impurity 13 (CAS CATO-C4X-197313)
- Doxapram Impurity 20 (CAS CATO-C4X-197320)
- Doxapram Impurity 10 (CAS 3192-92-5)
- Doxapram EP Impurity A (CAS 3192-64-1)
- Doxapram Impurity 32 (CAS CATO-C4X-197332)
- Doxapram Impurity 33 (CAS CATO-C4X-197333)
Recommended Standards
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- Emtricitabine Impurity 39 (CAS CATO-C4X-123239)
- Minodronic Acid Impurity 13 (CAS 127657-45-8)
- Ezetimibe Impurity 71 (CAS CATO-C4X-109871)
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- 5,5-Difluoroazepan-4-one hydrochloride (CAS 2097991-20-1)
- 2-(iodomethyl)-2-methyl-9-methylsulfonyl-1-oxaspiro[4.4]nonane (CAS 1869708-58-6)
- (2R,5S)-Methyl 5-methoxytetrahydrofuran-2-carboxylate (CAS 174689-92-0)
- 2-Chloro-1-(2-(4-fluorophenyl)morpholino)ethan-1-one (CAS 1184681-93-3)
- Tirzepatide Impurity 25 X TFA Salt (CAS CATO-C4X-324025)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com