2-Chloropyrimidine-5-boronic Acid CAS 1003845-06-4
| CAS No. | 1003845-06-4 |
| Molecular Formula | C4H4BClN2O2 |
| Molecular Weight | 158.35 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-Chloropyrimidine-5-boronic Acid (CAS 1003845-06-4), molecular formula C4H4BClN2O2 and molecular weight 158.35 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 2-Chloropyrimidine-5-boronic Acid (C4H4BClN2O2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 3.5, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 158.35 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 2-Chloropyrimidine-5-boronic Acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C4H4BClN2O2 |
| Molecular Weight | 158.35 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloropyrimidine Standards
- 2-Chloropyrimidine-4-carboxylic Acid (CAS 149849-92-3)
- 2-Chloropyrimidine-5-carboxylic Acid (CAS 374068-01-6)
- 4-Chloropyrimidine-5-carboxylic acid (CAS 933686-33-0)
- 5-Chloropyrimidine-4-carboxylic Acid (CAS 64224-65-3)
- 2-Chloropyrimidine-4-carboxamide, 97% (CAS 22536-66-9)
- 2-Chloropyrimidine-5-carboxamide (CAS 856595-94-3)
- 5-Chloropyrimidine-2-carboxamide (CAS 38275-59-1)
- 6-Chloropyrimidine-4-carboxamide (CAS 81333-06-4)
Recommended Standards
- 2,3,4,5-Tetrathiahexane (CAS 5756-24-1)
- (2-Chloropyrimidin-4-yl)boronic acid (CAS 1228431-85-3)
- 1-(Trimethylsilyl)piperazine (CAS 540494-46-0)
- (6-Chloropyrimidin-4-yl)boronic acid (CAS 1228431-87-5)
- N-Benzyl-1-(4-cyanophenyl)methanesulfonamide (CAS 923810-10-0)
- Propyl 2-(3-oxopiperazin-2-yl)acetate (CAS 90770-36-8)
- 2-(Bromomethyl)-4,5-diamino-3-(difluoromethyl)pyridine (CAS 1803670-32-7)
- 4,5,6,8-Tetrahydrobenzo[b]quinolino[1,8-gh][1,6]naphthyridine (CAS 7093-26-7)
- (E)-4,4,4-trifluorobut-2-enoic acid 4,4,4-trifluoro Crotonic acid 406-10-0 (CAS 406-10-0)
- 4H-Benzo[4,5]imidazo[1,2-b]pyrazol-2-amine (CAS 503560-15-4)
- 6-Bromo-1-cyclopentyl-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-1H-indazole-4-carboxamide (CAS 1346703-22-7)
- 1,3,5-Tris((trimethylsilyl)ethynyl)benzene (CAS 18772-58-2)
- 5-bromo-3-cyclopropyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine (CAS 1536688-88-6)
- (Tyr?)-C-Peptide (human) (CAS 57327-90-9)
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