N-Fmoc-2,5-difluoro-L-phenylalanine CAS 1004959-90-3
| CAS No. | 1004959-90-3 |
| Molecular Formula | C24H19F2NO4 |
| Molecular Weight | 423.41 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
N-Fmoc-2,5-difluoro-L-phenylalanine (CAS 1004959-90-3) is a high-purity analytical reference standard with the molecular formula C24H19F2NO4 and a molecular weight of 423.41 g/mol.
The molecular framework of N-Fmoc-2,5-difluoro-L-phenylalanine (C24H19F2NO4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), N-Fmoc-2,5-difluoro-L-phenylalanine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H19F2NO4 |
| Molecular Weight | 423.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related N Standards
- (S)-2-(Fmoc-amino)-3-(2,4-difluorophenyl)propanoic Acid (CAS 1032337-49-7)
- Fmoc-(S)-3-Amino-3-(3,4-Difluorophenyl)-propionic acid (CAS 1260596-69-7)
- Fmoc-(R)-3-Amino-3-(3,4-Difluorophenyl)-propionic acid (CAS 1260601-05-5)
- Fmoc-(S)-3-Amino-3-(2,4-Difluorophenyl)-propionic acid (CAS 1260601-06-6)
- Fmoc-(R)-3-Amino-3-(2,4-Difluorophenyl)-propionic acid (CAS 1260614-57-0)
- Fmoc-3,4-difluoro-L-phenylalanine (CAS 198560-43-9)
- FMOC-D-3,4-Difluorophenylalanine (CAS 198545-59-4)
- N-Fmoc-3,5-difluoro-L-phenylalanine (CAS 205526-24-5)
Recommended Standards
- S-(1,2-Dicarboxyethyl)glutathione (CAS 1115-52-2)
- 1-(4-Fluorobenzyl)-3-((4-fluorobenzyl)oxy)-N-(furan-2-ylmethyl)-1H-pyrazole-4-carboxamide (CAS 1013755-46-8)
- Dolutegravir-d4 (CAS CATO-CCAD304293)
- Urapidil Impurity 112 (CAS CATO-C4X-1924112)
- methyl 3-pyrrolidin-2-ylprop-2-ynoate (CAS 1896250-69-3)
- (S)-N,1-Dimethyl-4-methylenepyrrolidine-2-carboxamide (CAS 162281-70-1)
- 2-Bromobenzoyl cyanide (CAS 88562-26-9)
- 2-Butyl-1-((4-(diethylamino)phenyl)amino)-3-methylbenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile (CAS 442572-78-3)
- 2-Iodo-4-nitrobenzonitrile (CAS 300627-43-4)
- 1-(3-Fluoro-4-methylphenyl)hexan-1-one (CAS 1248062-87-4)
- 2-(2-(Pyrrolidin-1-yl)ethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS 933986-99-3)
- Bromobenzene-2,4,6-d3 (CAS 13122-41-3)
- 1-Benzyl-5-bromo-1H-1,2,4-triazole (CAS 1352925-80-4)
- Akt/SKG Substrate Peptide (CAS 276680-69-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com