Dolutegravir-d4 CAS CATO-CCAD304293
| CAS No. | CATO-CCAD304293 |
| Molecular Formula | - |
| Molecular Weight | 423.40 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Dolutegravir-d4 (CAS CATO-CCAD304293), molecular formula C20H15D4F2N3O5 and molecular weight 423.40 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Dolutegravir-d4 (C20H15D4F2N3O5) is characterized by deuterium isotope labeling, a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Dolutegravir-d4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H15D4F2N3O5 |
| Molecular Weight | 423.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >80% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Dolutegravir Standards
- Dolutegravir Impurity 47 (CAS CATO-C4X-162047)
- Dolutegravir Impurity 54 (CAS CATO-C4X-162054)
- Dolutegravir Impurity 44 (CAS 2518311-04-9)
- Dolutegravir (CAS 1051375-16-6)
- Dolutegravir Impurity 1 (CAS 1357289-29-2)
- Dolutegravir Impurity 11 (CAS 1973402-05-9)
- Dolutegravir Impurity 2 (CAS 1309560-49-3)
- Dolutegravir Impurity 4 (CAS 1357289-37-2)
Recommended Standards
- Urapidil Impurity 112 (CAS CATO-C4X-1924112)
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- N-Fmoc-2,5-difluoro-L-phenylalanine (CAS 1004959-90-3)
- 1-(4-chlorophenyl)-N-methylpiperidin-4-amine (CAS 144872-37-7)
- 5-Methyl-4-(4-methylphenyl)-4H-1,2,4-triazol-3-yl hydrosulfide (CAS 149747-23-9)
- 7-Fluoro-3-iodo-6-methoxy-1H-indazole (CAS 2484889-00-9)
- (2S)-2-methyl-1-(1-methyl-1H-pyrazole-4-carbonyl)piperazine hydrochloride (CAS 1909287-06-4)
- 2-(Difluoromethyl)-5-methoxy-6-(trifluoromethyl)pyridine-3-carboxylic acid (CAS 1805622-55-2)
- 2,2-difluoro-2-[(2R,3R,4S,5R,6R)-3,4,5-tribenzyloxy-6-(benzyloxymethyl)-2-hydroxy-tetrahydropyran-2-yl]acetic acid (CAS 953423-53-5)
- 2-Chloro-N-(2,4-dichlorobenzyl)-N-ethylacetamide (CAS 1353975-48-0)
- Lapatinib Impurity 46 (CAS 320337-10-8)
- [4-Fluoro-3-(piperidin-1-ylmethyl)phenyl]boronic acid (CAS 1200131-35-6)
- Insulin Degludec Impurity 3 (CAS CATO-C4X-21573)
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