(E)-3-(3-(4-Fluorophenyl)acryloyl)-4-hydroxy-6-methyl-2H-pyran-2-one CAS 1006372-29-7
| CAS No. | 1006372-29-7 |
| Molecular Formula | C15H11FO4 |
| Molecular Weight | 274.24 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
(E)-3-(3-(4-Fluorophenyl)acryloyl)-4-hydroxy-6-methyl-2H-pyran-2-one (CAS 1006372-29-7) is a high-purity analytical reference standard with the molecular formula C15H11FO4 and a molecular weight of 274.24 g/mol.
The molecular framework of (E)-3-(3-(4-Fluorophenyl)acryloyl)-4-hydroxy-6-methyl-2H-pyran-2-one (C15H11FO4) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), (E)-3-(3-(4-Fluorophenyl)acryloyl)-4-hydroxy-6-methyl-2H-pyran-2-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H11FO4 |
| Molecular Weight | 274.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
Related E Standards
- 2-(4-Fluorophenyl)-2-oxoethyl 4-hydroxybenzoate (CAS 386730-88-7)
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- 4-(4-Fluorophenyl)-6-(trifluoromethyl)pyrimidine-2-thiol (CAS 359899-79-9)
- 2-[N'-(4-Fluorophenyl)hydrazinecarbonyl]benzoic acid (CAS 320421-93-0)
- Methyl 3-((4-fluorophenyl)carbamoyl)isonicotinate (CAS 339101-54-1)
- 1,3-Bis(4-fluorophenyl)-2-methylpropane-1,3-dione (CAS 937602-30-7)
- 3-[2-(3-fluorophenyl)pyrrolidine-1-carbonyl]-5-methyl-1,2-oxazole (CAS 1031615-08-3)
- 3-(4-Fluorophenyl)-5H,6H,7H,8H,9H-imidazo[1,5-a]azepine-1-carboxylic acid (CAS 1050886-00-4)
Recommended Standards
- Disperse Yellow 9 (CAS 6373-73-5)
- N-(5-(Isoxazol-5-yl)-1,3,4-oxadiazol-2-yl)-1,5-dimethyl-1H-pyrazole-3-carboxamide (CAS 1013826-11-3)
- Dantrolene Impurity 3 (CAS 58136-76-8)
- 4,4,4-Trifluoro-1-(4-isopropoxyphenyl)butane-1,3-dione (CAS 1019340-50-1)
- 2-(4,7-Dibromo-1H-indol-3-yl)acetonitrile (CAS 1227572-17-9)
- 4-(Octan-2-ylamino)-4-oxobutanoic acid (CAS 732256-16-5)
- 1-(5-Chloro-2-methoxyphenyl)-1H-pyrrole (CAS 158966-65-5)
- 4-(4-Aminobenzamido)benzene-1-sulfonyl fluoride (CAS 19188-72-8)
- 6-Chloro-3-oxoisoindoline-5-sulfonamide (CAS 91862-45-2)
- 2-Chloro-n-[5-(5-cyclopropyl-1h-1,2,3,4-tetrazol-1-yl)-2-fluorophenyl]acetamide (CAS 1394041-32-7)
- 5-Ethyl-1-((tetrahydrofuran-2-yl)methyl)-1h-1,2,3-triazole-4-carboxylic acid (CAS 1249865-55-1)
- 2-(4-Pyridyl)indole (CAS 21182-07-0)
- H-D-Ala-OBzl · p-tosylate (CAS 41036-32-2)
- Tirzepatide Impurity 20 (CAS CATO-C4X-324020)
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