Ticagrelor Impurity N40 CAS 1006376-60-8
| CAS No. | 1006376-60-8 |
| Molecular Formula | C8H7ClF2O |
| Molecular Weight | 192.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ticagrelor Impurity N40.
As a process- or degradation-related impurity, Ticagrelor Impurity N40 (CAS 1006376-60-8, C8H7ClF2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system, Ticagrelor Impurity N40 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 192.59 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ticagrelor Impurity N40 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H7ClF2O |
| Molecular Weight | 192.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F/Cl-containing |
Related Ticagrelor Standards
- Ticagrelor Impurity 173 (CAS 1212376-05-0)
- Ticagrelor Impurity 135 (CAS CATO-C4X-1093135)
- Ticagrelor Impurity 78 (CAS 1351990-36-7)
- Ticagrelor impurity 136 (CAS 1932275-13-2)
- Ticagrelor Impurity 152 (CAS 1006376-62-0)
- Ticagrelor impurity 84（trans） (CAS 1006614-51-2)
- Ticagrelor Impurity 74 (CAS 220352-36-3)
- Ticagrelor Impurity 53 (CAS 145783-12-6)
Recommended Standards
- 2-Chloro-1,8-naphthyridine-3-carbaldehyde (CAS 1019200-44-2)
- 6-Chloro-2,3-difluorobenzeneethanol (CAS 887585-49-1)
- 1-Chlorophthalazine-6-carbaldehyde (CAS 1187244-53-6)
- 4-Chloro-1-(difluoromethoxy)-2-methylbenzene (CAS 639826-17-8)
- Mirabegron Impurity 120 (CAS CATO-C4X-1032120)
- Brivaracetam Impurity 189 (CAS CATO-C4X-2007189)
- Mirabegron impurity 119 (CAS CATO-C4X-1032119)
- 4-Chloro-2-iodo-1-isopropylbenzene (CAS 1369923-80-7)
- (3aS,4S,6R,6aR)-6-(6-amino-9H-purin-9-yl)-N-ethyl-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carboxamide (CAS 39491-53-7)
- 2-(3-Hydroxy-2,2-dimethylpropoxy)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile (CAS 2490666-02-7)
- trimethylpyrazine-2-carboxylic acid (CAS 186534-01-0)
- 1-(3-Bromophenyl)-1-methylethylamine (CAS 74702-93-5)
- 3,4,5-Tribromobenzene-1-thiol (CAS 443683-20-3)
- Semaglutide impurity 70 (CAS CATO-C4X-222670)
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