Ambrisentan Impurity 6 CAS 1007358-76-0
| CAS No. | 1007358-76-0 |
| Molecular Formula | C22H22N2O4 |
| Molecular Weight | 378.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Ambrisentan Impurity 6 (C22H22N2O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Ambrisentan Impurity 6 (CAS 1007358-76-0, C22H22N2O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H22N2O4 |
| Molecular Weight | 378.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 2 |
Related Ambrisentan Standards
- rac Ambrisentan (CAS 713516-99-5)
- Ambrisentan (CAS 177036-94-1)
- rac Ambrisentan-d3 (CAS 1189479-60-4)
- Ambrisentan-D10 (CAS 1046116-27-1)
- Ambrisentan Methyl Ester (CAS 1106685-61-3)
- rac Ambrisentan Methyl Ester (CAS 1240470-84-1)
- Ambrisentan 4-Hydroxymethyl Analog Racemate (CAS 1106685-84-0)
- rac Ambrisentan-d3 Methyl Ester (CAS 1329837-75-3)
Recommended Standards
- Guaifenesin EP Impurity C (CAS 1797132-23-0)
- Roxatidine Impurity 52 (CAS CATO-C4X-121352)
- Selexipag Impurity 25 (CAS 788152-32-9)
- Vonoprazan Impurity 257 (CAS CATO-C4X-1020257)
- Iopromide EP Impurity B (CAS 76350-28-2)
- Isavuconazole Impurity N18 (CAS 170863-34-0)
- Solriamfetol Impurity 31 (CAS CATO-C4X-256331)
- Isoescin IB (CAS 219944-46-4)
- Escin IA (CAS 123748-68-5)
- 9,9-Dimethyl-9,10-dihydroacridine (CAS 6267-02-3)
- (2R,3R)-3-((S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoic acid (CAS 863971-41-9)
- Eravacycline impurity 14 (CAS CATO-C4X-293814)
- 4-(6-(4-(2-Cyanophenyl)piperazin-1-yl)pyrazin-2-yl)benzamide (CAS 915373-23-8)
- Tirzepatide Impurity 59 (CAS CATO-C4X-324059)
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