Perphenazine EP Impurity A CAS 10078-25-8
| CAS No. | 10078-25-8 |
| Molecular Formula | C21H26ClN3O2S |
| Molecular Weight | 419.97 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Perphenazine EP Impurity A is closely related to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Perphenazine EP Impurity A (CAS 10078-25-8) is a certified pharmaceutical impurity reference standard with the molecular formula C21H26ClN3O2S and a molecular weight of 419.97 g/mol.
Structurally, Perphenazine EP Impurity A (C21H26ClN3O2S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 419.97 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H26ClN3O2S |
| Molecular Weight | 419.97 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1959 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Perphenazine Standards
- Perphenazine Impurity 6 (CAS 1254074-25-3)
- Perphenazine-D8 (as Dihydrochloride) (CAS 1189961-11-2)
- Perphenazine-d4 (CAS 155593-75-2)
- Perphenazine (CAS 58-39-9)
- Perphenazine EP Impurity B (CAS 3533-97-9)
- Perphenazine Impurity C27 (CAS 2765-59-5)
- Perphenazine Impurity 5 (CAS 2760728-14-9)
- Perphenazine Impurity 8 (CAS 890122-55-1)
Recommended Standards
- 7-Hydroxy Perphenazine (CAS 52174-38-6)
- 6-{[(4-chlorophenyl)sulfanyl]methyl}-2-{[(4-fluorophenyl)methyl]sulfanyl}-N,N-dimethylpyrimidin-4-amine (CAS 341965-50-2)
- Prochlorperazine Impurity 8 (CAS CATO-C4X-19668)
- 3-(4-Chlorophenyl)-5-((2,5-dimethylbenzyl)thio)-4-(p-tolyl)-4H-1,2,4-triazole (CAS 477330-28-2)
- Nerandomilast impurity 11 (CAS CATO-C4X-347311)
- Propofol Impurity 29 (CAS 84633-54-5)
- N-Nitroso Fedratinib Impurity 3 (CAS CATO-C4X-30883)
- 5-Bromo-2-(chloromethyl)benzo[d]oxazole (CAS 110704-48-8)
- 4-(6-Thiocarbamoyl-2-benzimidazolyl)thiobenzamide (CAS 1256482-81-1)
- Allyl 1H,1H-heptafluorobutyl ether (CAS 648-42-0)
- 5-Bromo-2-phenethylpyridin-3-amine (CAS 1856683-81-2)
- Methyl 2-{[(4-chlorophenyl)methylene]amino}-3-phenylpropanoate (CAS 1194761-35-7)
- 5-(4,5-Dihydrooxazol-2-yl)-3-methylisoxazole (CAS 7186-60-9)
- Liraglutide Impurity 18 TFA Salt (CAS CATO-C4X-199218)
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