Proparacaine Impurity N1 CAS 100811-81-2
| CAS No. | 100811-81-2 |
| Molecular Formula | C13H19ClN2O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Proparacaine Impurity N1.
As a process- or degradation-related impurity, Proparacaine Impurity N1 (CAS 100811-81-2, C13H19ClN2O2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Proparacaine Impurity N1 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 307.22 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Proparacaine Impurity N1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H19ClN2O2 HCl |
| Molecular Weight | 307.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Proparacaine Standards
- Proparacaine Impurity 25 HCl (CAS 1081544-05-9)
- Proparacaine Impurity 20 (CAS 1216179-28-0)
- Proparacaine Impurity 16 (CAS 15788-85-9)
- Proparacaine Impurity 15 (CAS 2102411-30-1)
- Proparacaine Impurity 23 HCl (CAS 2102411-30-1(Free Base))
- Proparacaine Impurity 17 (CAS 2731368-98-0)
- Proparacaine Impurity 5 DiHCl (CAS 2731368-99-1)
- Proparacaine Impurity 24 (CAS 2815508-81-5)
Recommended Standards
- Telmisartan Impurity 101 (CAS 1338830-39-9)
- Rosuvastatin Impurity 146 (CAS 148809-28-3)
- HO-Ste-γGlu-AEEA-OH (CAS CATO-C4X-2226278)
- 1-(2-aminoethyl)-1,2-dihydropyridin-2-one dihydrochloride (CAS 1384428-69-6)
- (R)-1-(4-fluoro-1-phenyl-1H-benzo[d]imidazol-2-yl)ethan-1-amine (CAS 1398507-84-0)
- Halometasone impurity 13 (CAS CATO-C4X-144613)
- 4-Methoxy-7-methyl-2-piperazin-1-yl-1,3-benzothiazole (CAS 1204296-73-0)
- Tesetaxel (CAS 333754-36-2)
- 2-chloro-N-{4-[(4-methylpiperidin-1-yl)methyl]-1,3-thiazol-2-yl}acetamide hydrochloride (CAS 1803597-34-3)
- Semaglutide impurity 109 (CAS CATO-C4X-2226109)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com