Proparacaine Impurity 5 DiHCl CAS 2731368-99-1
| CAS No. | 2731368-99-1 |
| Molecular Formula | C16H26N2O4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 346.85 g/mol gives Proparacaine Impurity 5 DiHCl distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Proparacaine Impurity 5 DiHCl (CAS 2731368-99-1) is a certified pharmaceutical impurity reference standard with the molecular formula C16H26N2O4HCl and a molecular weight of 346.85 g/mol.
The molecular framework of Proparacaine Impurity 5 DiHCl (C16H26N2O4HCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Proparacaine Impurity 5 DiHCl under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H26N2O4 2*HCl |
| Molecular Weight | 346.85 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2002 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Proparacaine Standards
- Proparacaine Impurity N1 (CAS 100811-81-2)
- Proparacaine Impurity 25 HCl (CAS 1081544-05-9)
- Proparacaine Impurity 20 (CAS 1216179-28-0)
- Proparacaine Impurity 16 (CAS 15788-85-9)
- Proparacaine Impurity 15 (CAS 2102411-30-1)
- Proparacaine Impurity 23 HCl (CAS 2102411-30-1(Free Base))
- Proparacaine Impurity 17 (CAS 2731368-98-0)
- Proparacaine Impurity 24 (CAS 2815508-81-5)
Recommended Standards
- Vilazodone Impurity 6 (CAS 183288-47-3)
- N-Nitroso Ponatinib Metabolite Impurity 23 (CAS CATO-C4X-226923)
- Nalmefene impurity 20 (CAS 738552-29-9)
- 2,3-Difluorophenol (CAS 6418-38-8)
- 3-(Methylsulfanyl)-5,6-diphenyl-1,2,4-triazine (CAS 28735-33-3)
- 4-Amino-1,2-dimethylpiperidine (CAS 89850-92-0)
- 7-Methyl-3H-pyrrolizin-3-one (CAS 154367-56-3)
- (5-(4-Methoxyphenyl)-3-methylisoxazol-4-yl)methanol (CAS 113841-95-5)
- Furan-2-yl(3-methoxyphenyl)methanol (CAS 944523-02-8)
- Semaglutide impurity 49 (CAS CATO-C4X-222649)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com