Proparacaine Impurity 25 HCl CAS 1081544-05-9
| CAS No. | 1081544-05-9 |
| Molecular Formula | C14H22N2O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Proparacaine Impurity 25 HCl (CAS 1081544-05-9) is a certified pharmaceutical impurity reference standard with the molecular formula C14H22N2O3HCl and a molecular weight of 302.80 g/mol.
Based on its molecular formula C14H22N2O3HCl, Proparacaine Impurity 25 HCl contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 302.80 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H22N2O3 HCl |
| Molecular Weight | 302.80 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Proparacaine Standards
- Proparacaine Impurity N1 (CAS 100811-81-2)
- Proparacaine Impurity 20 (CAS 1216179-28-0)
- Proparacaine Impurity 16 (CAS 15788-85-9)
- Proparacaine Impurity 15 (CAS 2102411-30-1)
- Proparacaine Impurity 23 HCl (CAS 2102411-30-1(Free Base))
- Proparacaine Impurity 17 (CAS 2731368-98-0)
- Proparacaine Impurity 5 DiHCl (CAS 2731368-99-1)
- Proparacaine Impurity 24 (CAS 2815508-81-5)
Recommended Standards
- Linezolid Impurity 26 (CAS 168828-89-5)
- Tandospirone Impurity 9 HCl (CAS 33386-20-8(Free Amide))
- Ramelteon Impurity N33 (CAS 196597-17-8)
- Bis-aminooxy-PEG1 (CAS 93460-33-4)
- 2-(2-Ethoxy-4-formylphenoxy)propanoic acid (CAS 51264-80-3)
- 2-(Chloromethyl)-3-(difluoromethyl)pyridine-5-carboxylic acid (CAS 1806805-26-4)
- 6-Hydroxy Chlorzoxazone-d2 (CAS 1432065-00-3)
- 2-Methyl-1,3,2-dioxaborinane (CAS 51901-48-5)
- 3-(Allylamino)tetrahydrothiophene 1,1-dioxide (CAS 194788-58-4)
- Bax inhibitor peptide V5 (CAS 579492-81-2)
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