2-(Difluoromethyl)pyrimidin-5-ol CAS 100991-19-3
| CAS No. | 100991-19-3 |
| Molecular Formula | C5H4F2N2O |
| Molecular Weight | 146.09 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-(Difluoromethyl)pyrimidin-5-ol (CAS 100991-19-3), molecular formula C5H4F2N2O and molecular weight 146.09 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to an amide group, a hydroxyl group, an ether linkage, fluorine substitution, 2-(Difluoromethyl)pyrimidin-5-ol is typically off-white to pale yellow liquid. Its solid-state physicochemical attributes — including a molecular weight of 146.09 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), 2-(Difluoromethyl)pyrimidin-5-ol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H4F2N2O |
| Molecular Weight | 146.09 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Difluoromethyl Standards
- 1-(Difluoromethyl)-1H-pyrazole-4-carbaldehyde (CAS 1216244-84-6)
- 1-(Difluoromethyl)-1h-imidazole-2-carbaldehyde (CAS 1248811-92-8)
- 6-(Difluoromethyl)pyrazin-2(1H)-one (CAS 1261630-68-5)
- 6-(Difluoromethyl)pyrimidin-4(3H)-one (CAS 126538-89-4)
- 1-(Difluoromethyl)-1H-pyrazole-3-carbaldehyde (CAS 1432681-54-3)
- 4-(Difluoromethyl)pyrimidin-2(1H)-one (CAS 1522243-39-5)
- 5-(Difluoromethyl)furan-2-carbaldehyde (CAS 152932-57-5)
- 5-(Difluoromethyl)-3-Furaldehyde (CAS 153026-75-6)
Recommended Standards
- Ethyl 1,1,2,2-Tetrafluoroethyl Ether (CAS 512-51-6)
- 4-Amino-3,5-difluoropyridin-2(1H)-one (CAS 105252-96-8)
- 5-Fluoropyrimidine-2,4,6-triol (CAS 767-80-6)
- 3,3,4,4-Tetrafluorobutan-1-ol (CAS 428-90-0)
- 1-(4-Ethylphenyl)-1H-pyrazol-5-amine (CAS 1368947-90-3)
- H-Gly-Arg-Gly-Asp-OH (CAS 97461-81-9)
- (-)-Sparteine (CAS 90-39-1)
- 5-(Hexylthio)-1,3,4-thiadiazol-2-amine (CAS 61516-63-0)
- 2-chloro-5-vinylpyrimidine (CAS 131467-06-6)
- 2-Amino-1-(2-((benzyl(ethyl)amino)methyl)piperidin-1-yl)ethanone (CAS 1353968-18-9)
- (3AS,7aS)-2-Methyl-octahydro-3H-pyrrolo[3,4-c]pyridin-3-one (CAS 1363378-09-9)
- 4,6-Dichloropyridazine-3-carbonitrile (CAS 35857-90-0)
- 4-(tert-Butoxy)-2-isopropylphenol (CAS 1243279-80-2)
- Influenza PR8 Hemagglutinin Peptide (110-119) (H-6312.0005) (CAS 132031-50-6)
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