Quetiapine EP Impurity P CAS 1011758-03-4
| CAS No. | 1011758-03-4 |
| Molecular Formula | C19H21N3S |
| Molecular Weight | 323.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Quetiapine EP Impurity P (C19H21N3S) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality. Its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Quetiapine EP Impurity P (CAS 1011758-03-4, C19H21N3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H21N3S |
| Molecular Weight | 323.46 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Quetiapine Standards
- Quetiapine Impurity 68 (CAS CATO-C4X-124468)
- Quetiapine impurity 77 (CAS CATO-C4X-124477)
- Quetiapine DBTP N-Methyl Impurity (CAS 1977-09-9)
- Quetiapine EP Impurity I (CAS 329216-67-3)
- Quetiapine EP Impurity B-d8 (CAS 1189866-35-0)
- Quetiapine impurity 75 (CAS CATO-C4X-124475)
- Quetiapine Hydroxy Impurity-d8 (CAS 1246820-78-9)
- Quetiapine EP Impurity T (CAS 5747-46-6)
Recommended Standards
- N-[(2Z)-3-tert-Butyl-4-phenyl-2,3-dihydro-1,3-thiazol-2-ylidene]-1-(pyridin-4-yl)methanamine (CAS 866009-91-8)
- Tetrabenazine Impurity 38-d6 (CAS 2244238-16-0)
- N-[(2Z)-3-tert-Butyl-4-phenyl-2,3-dihydro-1,3-thiazol-2-ylidene]-1-(pyridin-3-yl)methanamine (CAS 866009-97-4)
- Tetrabenazine Impurity 49 (CAS CATO-C4X-274849)
- Minocycline Impurity 67 (CAS CATO-C4X-169967)
- Ketorolac Impurity 41 (CAS 136116-84-2)
- Edoxaban Impurity 16 (CAS CATO-C4X-106316)
- 3-(Cyclobutanecarboxamido)-[1,2,4]triazolo[4,3-a]pyridine-8-carboxylic acid (CAS 1206969-16-5)
- 5-(((9H-fluoren-9-yl)methoxy)carbonyl)-5-azaspiro[2.3]Hexane-4-carboxylic acid (CAS 2225141-14-8)
- 4-Bromo-2,3-difluorophenylacetonitrile (CAS 1627857-25-3)
- (4-Chlorophenyl)(2-phenylmorpholino)methanone (CAS 922341-51-3)
- 3-Cyclohexyl-N-hydroxypropanamide (CAS 651738-74-8)
- 2-(4-Methoxyphenoxy)-1-methyl-1H-indole-3-carbaldehyde (CAS 338416-68-5)
- Semaglutide impurity 66 (CAS CATO-C4X-222666)
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