Chlorpheniramine Impurity 41 CAS 101286-08-2
| CAS No. | 101286-08-2 |
| Molecular Formula | C16H19ClN2 |
| Molecular Weight | 274.79 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Chlorpheniramine Impurity 41 (C16H19ClN2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 274.79 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Chlorpheniramine Impurity 41 (CAS 101286-08-2, C16H19ClN2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H19ClN2 |
| Molecular Weight | 274.79 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chlorpheniramine Standards
- Chlorpheniramine Impurity 19 (CAS CATO-C4X-118819)
- Chlorpheniramine Impurity 36 (CAS CATO-C4X-118836)
- Chlorpheniramine Impurity 38 (CAS CATO-C4X-118838)
- Chlorpheniramine (CAS 132-22-9)
- Chlorpheniramine-d6 (CAS 1185054-60-7)
- Chlorpheniramine Impurity 14 (CAS CATO-C4X-118814)
- R-Chlorpheniramine N-Oxide (CAS 142494-45-9)
- Chlorpheniramine Impurity 15 (CAS 120244-82-8)
Recommended Standards
- (2-Chloro-1-ethoxy-2,2-difluoroethoxy)triethylsilane (CAS 1922958-25-5)
- 5-((2-Chlorobenzyl)thio)-1,3,4-thiadiazole-2-thiol (CAS 345991-75-5)
- tert-butyl 7-chloro-3,4-dihydro-2H-1,8-naphthyridine-1-carboxylate (CAS 679392-23-5)
- 5-((3-Chlorobenzyl)thio)-1,3,4-thiadiazole-2(3H)-thione (CAS 444791-16-6)
- Vardenafil Impurity 38 (CAS 224787-06-8)
- Ranitidine Impurity 17 (CAS CATO-C4X-137017)
- Oseltamivir Impurity 104 (CAS 204254-92-2)
- 2-Amino-6-iodoquinazolin-4(1H)-one (CAS 900475-01-6)
- 4-Cyclopropyl-1-isopropyl-1H-indole-3-carbaldehyde (CAS 1350760-56-3)
- 2-[Butyl(methyl)amino]nicotinic acid (CAS 1019465-94-1)
- n-(2-Bromo-4-methylphenyl)-3-(tetrahydrofuran-2-yl)propanamide (CAS 1147838-81-0)
- 1-Cyclobutanecarbonyl-1,2,3,4-tetrahydro-1,5-naphthyridine (CAS 1311868-01-5)
- N1-(2,5-Difluorophenyl)-N2-(furan-2-ylmethyl)oxalamide (CAS 899956-48-0)
- Neuropeptide W-23 (human) (CAS 383415-79-0)
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