Palbociclib Impurity 25 CAS 1016636-76-2
| CAS No. | 1016636-76-2 |
| Molecular Formula | C13H13BrClN3O |
| Molecular Weight | 342.62 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Palbociclib Impurity 25.
As a process- or degradation-related impurity, Palbociclib Impurity 25 (CAS 1016636-76-2, C13H13BrClN3O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C13H13BrClN3O, Palbociclib Impurity 25 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine/bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 342.62 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Palbociclib Impurity 25 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H13BrClN3O |
| Molecular Weight | 342.62 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 3 |
Related Palbociclib Standards
- Palbociclib Impurity 114 (CAS 412348-27-7)
- Palbociclib Impurity 3 (CAS 153747-97-8)
- Palbociclib Impurity 4 (CAS 1774897-13-0)
- Palbociclib Impurity 98 (CAS 2340184-77-0)
- Palbociclib Impurity 155 (CAS CATO-C4X-1125155)
- Palbociclib impurity 161 (CAS CATO-C4X-1125161)
- Palbociclib Impurity 68 (CAS 2444702-87-6)
- Palbociclib Impurity 158 (CAS 2639903-34-5)
Recommended Standards
- 2-(Trifluoromethyl)-5-(4-(trifluoromethyl)phenyl)furan-3-carbonyl chloride (CAS 240122-23-0)
- 8-Chloro-2-(5-chloro-2-thienyl)quinoline-4-carbonyl chloride (CAS 1160256-92-7)
- (R)-9-bromo-10-chloro-1,2,3,4,12,12a-hexahydro-6H-benzo[f]pyrazino[2,1-c][1,4]oxazepine-8-carbonitrile (CAS 2487480-32-8)
- 6-Chloro-2-(5-chloro-2-thienyl)quinoline-4-carbonyl chloride (CAS 1160263-10-4)
- Brivaracetam impurity 85 (CAS CATO-C4X-200785)
- Landiolol Impurity 46 (CAS 57044-24-3)
- Arbidol Impurity 42 (CAS 153633-14-8)
- Methyl n-(5-amino-2-fluorophenyl)carbamate (CAS 68621-95-4)
- 6-[(2r)-1-hydroxy-3-methylbutan-2-yl]-5h,6h,7h-pyrrolo[3,4-b]pyridin-5-one (CAS 1268952-43-7)
- n-{4-[4-(propan-2-yloxy)phenyl]butan-2-ylidene}hydroxylamine (CAS 1017040-19-5)
- 2-Fluoro-n-(3-methoxypropyl)benzene-1-sulfonamide (CAS 790263-29-5)
- 2,4-Dichloro-6-(dibenzo[b,d]furan-3-yl)-1,3,5-triazine (CAS 2102042-41-9)
- 3-(Bromomethyl)-5-fluoro-1H-indole (CAS 1823923-38-1)
- Anti-TF Antigen Peptide P30-1 trifluoroacetate salt (CAS 573664-50-3)
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