Ethyl 1-(2-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate CAS 1020237-74-4
| CAS No. | 1020237-74-4 |
| Molecular Formula | C13H10ClF3N2O2 |
| Molecular Weight | 318.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Ethyl 1-(2-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (C13H10ClF3N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Ethyl 1-(2-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (CAS 1020237-74-4), molecular formula C13H10ClF3N2O2 and molecular weight 318.68 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Ethyl 1-(2-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H10ClF3N2O2 |
| Molecular Weight | 318.68 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Ethyl Standards
- Ethyl 1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (CAS 112055-35-3)
- Ethyl 1-(4-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (CAS 112055-36-4)
- Ethyl 4-(4-chlorophenyl)-2-(trifluoromethyl)-1h-imidazole-5-carboxylate (CAS 162700-26-7)
- Ethyl 5-(4-chlorophenyl)-2-(trifluoromethyl)furan-3-carboxylate (CAS 175276-59-2)
- 3-(4-Chlorophenyl)-1-(2,4-difluorophenyl)-1H-pyrazole-4-carbaldehyde (CAS 618098-76-3)
- N-[5-(3-Chlorophenyl)-2,7-dioxo-1,2,4,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]acetamide (CAS 1257440-43-9)
- N-(2-Chlorophenyl)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxamide (CAS 297146-24-8)
- 1-[(3-Chlorophenyl)methyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole (CAS 1415825-07-8)
Recommended Standards
- 3-Chloro-5-nitro-2-(4-nitrophenyl)-2H-indazole (CAS 88279-21-4)
- 2-(2-Chloro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid ethyl ester (CAS 1033586-26-3)
- N1,N1-dimethyl-3,5-di(trifluoromethyl)benzene-1-carbohydrazonoyl chloride (CAS 286009-02-7)
- Methyl 5-chloro-2-(trifluoromethylsulfonyloxy)benzoate (CAS 494210-98-9)
- 2-Bromo-5-(bromomethyl)-4-(difluoromethyl)pyridine (CAS 1805310-34-2)
- (2,3-Dihydrofuro[3,2-b]pyridin-6-yl)methanol (CAS 227752-44-5)
- N-(1-(tert-Butyl)-1H-pyrazol-5-yl)-6-chloropyrazin-2-amine (CAS 1010086-61-9)
- 5-Bromo-4-(chloromethyl)-2-fluoropyridine (CAS 1227562-25-5)
- N-(N-(3,4-dimethylphenyl)carbamimidoyl)hydrazinecarboximidamide hydrochloride (CAS 1171647-17-8)
- 2-Amino-4-hydroxy-6-isopropylprimidine 2-amino-6-isopropylpyrimidin-4-ol 73576-32-6 (CAS 73576-32-6)
- 1-((4-Bromothiophen-2-yl)methyl)-3,5-dimethyl-1h-pyrazol-4-amine (CAS 1247076-44-3)
- 3-Cyclopentyl-1-({1-[4-methyl-2-(pyridin-3-yl)-1,3-thiazol-5-yl]ethylidene}amino)urea (CAS 1356819-44-7)
- n-(4-Bromobenzyl)-3-methoxypropan-1-amine (CAS 106027-50-3)
- Semaglutide impurity 267 (CAS CATO-C4X-2226267)
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