Ibrutinib Impurity 10 CAS 1022150-12-4
| CAS No. | 1022150-12-4 |
| Molecular Formula | C22H22N6O |
| Molecular Weight | 386.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ibrutinib Impurity 10 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Ibrutinib Impurity 10 (CAS 1022150-12-4, C22H22N6O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Ibrutinib Impurity 10 (C22H22N6O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ibrutinib Impurity 10 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H22N6O |
| Molecular Weight | 386.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 6 |
Related Ibrutinib Standards
- Ibrutinib Impurity 24 (CAS 330785-90-5)
- Ibrutinib Impurity 25 (CAS CATO-C4X-106425)
- Ibrutinib Impurity 174 (CAS CATO-C4X-1064174)
- Ibrutinib Impurity 195 (CAS CATO-C4X-1064195)
- Ibrutinib Impurity 35 (CAS CATO-C4X-106435)
- Ibrutinib Impurity 197 (CAS CATO-C4X-1064197)
- Ibrutinib Impurity 83 (CAS CATO-C4X-106483)
- Ibrutinib Impurity 158 (CAS CATO-C4X-1064158)
Recommended Standards
- N-Cyclopentyl-2-((3-(4-fluorobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)acetamide (CAS 863457-96-9)
- 5-Benzyl-2-(4-benzyl-3-methyl-5-oxo-2,5-dihydro-1H-pyrazol-1-yl)-6-methyl-3,4-dihydropyrimidin-4-one (CAS 866137-70-4)
- Imatinib Impurity 95 (CAS 1642630-12-3)
- 5,12-Diphenyl-5,12-dihydroquinoxalino[2,3-b]quinoxaline (CAS 2361129-09-9)
- Ezetimibe Impurity 78 (CAS CATO-C4X-109878)
- Fondaparinux Sodium Impurity 10 (CAS CATO-C4X-205210)
- Abemaciclib Impurity 186 (CAS 2137067-02-6)
- 4-(Tributylstannyl)pyrimidine (CAS 332133-92-3)
- 2-Amino-4,5-diphenylfuran-3-carbonitrile (CAS 5503-73-1)
- 2-Acetyl-7-methoxybenzofuran (CAS 43071-52-9)
- 5-Bromo-2-(4-fluorophenyl)-4-methoxypyridazin-3(2H)-one (CAS 221031-02-3)
- N-((3-(1-Ethyl-1H-pyrrol-2-yl)-1,2,4-oxadiazol-5-yl)methyl)-3-(thiophen-2-yl)acrylamide (CAS 2035019-32-8)
- (2R,3S)-tert-Butyl 3-amino-2-(hydroxymethyl)pyrrolidine-1-carboxylate (CAS 2603403-24-1)
- Des-Gly29,30-Tirzepatide (CAS CATO-CPTD788944)
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