Naltrexone Impurity 23 CAS 102272-79-7
| CAS No. | 102272-79-7 |
| Molecular Formula | C22H25NO8 |
| Molecular Weight | 431.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Naltrexone Impurity 23 (CAS 102272-79-7, C22H25NO8) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Naltrexone Impurity 23 (C22H25NO8) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H25NO8 |
| Molecular Weight | 431.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Nitrogen Atoms | 1 |
Related Naltrexone Standards
- Naltrexone Impurity 34 (CAS 153567-11-4)
- Naltrexone impurity 54 (CAS CATO-C4X-147554)
- Naltrexone Impurity 62 (CAS CATO-C4X-147562)
- Naltrexone EP Impurity E (CAS 767615-69-0)
- Naltrexone impurity 37 (CAS CATO-C4X-147537)
- Naltrexone impurity 53 (CAS CATO-C4X-147553)
- Naltrexone Impurity 21 (CAS 64643-76-1)
- Naltrexone Impurity 15 (CAS 111129-14-7)
Recommended Standards
- 25024-53-7 N-(tert-Butoxycarbonyl)-1-(2,4-dinitrophenyl)-L-histidine L-Histidine, N-((1,1-dimethylethoxy)carbonyl)-1-(2,4-dinitrophenyl)- N-((1,1-Dimethylethoxy)carbonyl)-1-(2,4-dinitrophenyl)-L-histidine EINECS 246-569-0 (CAS 25024-53-7)
- Noscapine impurity 5 (CAS 55836-07-2)
- tert-Butyl (7-((3aS,4S,6R,6aS)-6-cyano-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)carbamate (CAS 2691070-10-5)
- Rimsulfuron (CAS 122931-48-0)
- Nemonoxacin Impurity 117 (CAS CATO-C4X-3128117)
- Norfloxacin Impurity 44 (CAS 140700-98-7)
- Meropenem Impurity 44 (CAS 1332594-11-2)
- Methyl 7-methoxy-1H-indole-5-carboxylate, 97% (CAS 180624-24-2)
- 1,2,5-Trifluoro-4-methyl-3-trifluoromethyl-benzene (CAS 933674-92-1)
- 5-Methyl-2-phenylpyrazolo[1,5-a]pyrimidine (CAS 144205-23-2)
- 4-Amino-1-(pyrrolidin-1-yl)butan-1-one (CAS 244789-38-6)
- 4-Bromo-3-chloro-1-methyl-1H-pyrazole (CAS 1350323-83-9)
- 5-(3-Fluorophenoxy)pentan-1-ol (CAS 1184787-17-4)
- D-Leu26-Tirzepatide (CAS CATO-CPTD788908)
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