Palbociclib Impurity 6 CAS 1023594-49-1
| CAS No. | 1023594-49-1 |
| Molecular Formula | C14H22N4O2 |
| Molecular Weight | 278.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Palbociclib Impurity 6 (CAS 1023594-49-1), a pharmacopoeial impurity reference standard (molecular formula C14H22N4O2, MW 278.35 g/mol) used for the identification and quantification of trace impurities in APIs.
Palbociclib Impurity 6 (C14H22N4O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H22N4O2 |
| Molecular Weight | 278.35 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 4 |
Related Palbociclib Standards
- Palbociclib Impurity 110 (CAS 571189-23-6)
- Palbociclib Impurity 26 (CAS 1023594-50-4)
- Palbociclib Impurity 27 (CAS 1245914-05-9)
- Palbociclib Impurity 28 (CAS 571188-59-5)
- Palbociclib Impurity 31 (CAS 733039-20-8)
- Palbociclib Impurity 67 (CAS 1823404-28-9)
- Palbociclib Impurity 199 (E-Isomer) (CAS CATO-C4X-1125199)
- Palbociclib Impurity 138 (CAS CATO-C4X-1125138)
Recommended Standards
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- Sulpiride EP Impurity F (CAS 2214214-03-4)
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- Methyl 5-hydrazinyl-2-(p-tolyl)oxazole-4-carboxylate (CAS 663177-20-6)
- Tert-butyl (3aR,4S,6aR)-4-(trifluoromethyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate (CAS 1251001-26-9)
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- Allo-Thr5-Tirzepatide (CAS CATO-CPTD788934)
Why CATO?
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