Avanafil Impurity N1 CAS 859517-85-4
| CAS No. | 859517-85-4 |
| Molecular Formula | C7H8ClNO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Avanafil Impurity N1 (CAS 859517-85-4) is a certified pharmaceutical impurity reference standard with the molecular formula C7H8ClNOHBr and a molecular weight of 238.51 g/mol.
Based on its molecular formula C7H8ClNOHBr, Avanafil Impurity N1 contains an amide group, a hydroxyl group, an ether linkage, chlorine/bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 238.51 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H8ClNO HBr |
| Molecular Weight | 238.51 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 1 |
Related Avanafil Standards
- Avanafil Impurity 77 (CAS 1201936-61-9)
- Avanafil Impurity 160 (CAS 1202002-16-1)
- Avanafil Impurity 3 (CAS 1364671-52-2)
- Avanafil Impurity 2 (CAS 1364671-62-4)
- Avanafil Impurity 110 (CAS 1368440-33-8)
- Avanafil Impurity 4 (CAS 1452128-53-8)
- Avanafil Impurity 133 (CAS 1508194-63-5)
- Avanafil Impurity 46 (CAS 1624833-89-1)
Recommended Standards
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- 12-(Trimethylsilyl)isoindolo[2,1-b]isoquinolin-7(5H)-one (CAS 646029-43-8)
- 2-(Chloromethyl)-6-(difluoromethyl)-4-iodopyridine-3-carboxylic acid (CAS 1805610-86-9)
- Pent-4-yn-1-yl benzoate (CAS 100330-28-7)
- Bis(2-dichlorophosphinophenyl) ether (CAS 1293994-89-4)
- Perampanel Impurity 36 (CAS CATO-C4X-243036)
- Formaldehyde-2,4-Dinitrophenylhydrazone (CAS 1081-15-8)
- Semaglutide Impurity 177 (CAS CATO-C4X-2226177)
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