3-Isopropyl-8,9-dimethoxy-5-((3-(trifluoromethyl)benzyl)thio)imidazo[1,2-c]quinazolin-2(3H)-one CAS 1024595-16-1
| CAS No. | 1024595-16-1 |
| Molecular Formula | C23H22F3N3O3S |
| Molecular Weight | 477.50 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3-Isopropyl-8,9-dimethoxy-5-((3-(trifluoromethyl)benzyl)thio)imidazo[1,2-c]quinazolin-2(3H)-one is closely related to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
3-Isopropyl-8,9-dimethoxy-5-((3-(trifluoromethyl)benzyl)thio)imidazo[1,2-c]quinazolin-2(3H)-one (CAS 1024595-16-1), molecular formula C23H22F3N3O3S and molecular weight 477.50 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-Isopropyl-8,9-dimethoxy-5-((3-(trifluoromethyl)benzyl)thio)imidazo[1,2-c]quinazolin-2(3H)-one (C23H22F3N3O3S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H22F3N3O3S |
| Molecular Weight | 477.50 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
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Recommended Standards
- 8,9-Dimethoxy-3-(propan-2-yl)-5-({[4-(trifluoromethyl)phenyl]methyl}sulfanyl)-2H,3H-imidazo[1,2-c]quinazolin-2-one (CAS 1024020-20-9)
- 8,9-Dimethoxy-3-(propan-2-yl)-5-({[2-(trifluoromethyl)phenyl]methyl}sulfanyl)-2H,3H-imidazo[1,2-c]quinazolin-2-one (CAS 1030881-50-5)
- Azlocillin Oxide Impurity (CAS CATO-C4X-23201)
- (3-Amino-4-(trifluoromethyl)-6,7-dihydro-5H-cyclopenta[b]thieno[3,2-e]pyridin-2-yl)(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methanone (CAS 627053-27-4)
- 2-(1-Piperidinyl)propanoic acid (CAS 69181-71-1)
- 2-(Diethylamino)benzo[d]thiazol-6-ol (CAS 75105-05-4)
- (5-(1-Methyl-1H-pyrazol-4-yl)pyridin-3-yl)methanamine dihydrochloride (CAS 1949816-16-3)
- 1-Amino-2-methylpropan-2-olhydrochloride (CAS 30533-50-7)
- 5-(Iodomethyl)oxazolidin-2-one (CAS 107175-73-5)
- 1-(3,4-Dihydro-2H-pyrrol-5-yl)-1-phenyl-3-(p-tolyl)urea (CAS 400870-08-8)
- 6-Methoxy-4-methylquinoline hydrochloride (CAS 7461-59-8)
- Amifostine Impurity 8 (CAS 33759-44-3)
- 3-Amino-N-methyl-N-phenylpropanamide (CAS 99169-48-9)
- Insulin Degludec Impurity 7 (CAS CATO-C4X-21577)
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