Pethidine EP Impurity A HCl CAS 10272-50-1
| CAS No. | 10272-50-1 |
| Molecular Formula | C12H17N |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Pethidine EP Impurity A HCl is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Pethidine EP Impurity A HCl (CAS 10272-50-1), a pharmacopoeial impurity reference standard (molecular formula C12H17NHCl, MW 211.73 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Pethidine EP Impurity A HCl (C12H17NHCl) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H17N HCl |
| Molecular Weight | 211.73 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1959 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Pethidine Standards
- Pethidine Impurity 12 (CAS 13147-07-4)
- Pethidine-d5 Hydrochloride (CAS 1330180-05-6)
- Pethidine Impurity 3 (CAS 158984-76-0)
- Pethidine EP Impurity B HCl (CAS 23007-85-4)
- Pethidine EP Impurity D (CAS 28030-27-5)
- Pethidine EP Impurity B (CAS 28289-54-5)
- Pethidine Impurity N33 (CAS 50-13-5)
- Pethidine Impurity 1 (CAS 51281-64-2)
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