Pethidine Impurity 12 CAS 13147-07-4
| CAS No. | 13147-07-4 |
| Molecular Formula | C15H21NO3 |
| Molecular Weight | 263.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Pethidine Impurity 12 (CAS 13147-07-4, C15H21NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Pethidine Impurity 12 (C15H21NO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H21NO3 |
| Molecular Weight | 263.33 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 0.95 |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1960 |
| Nitrogen Atoms | 1 |
Related Pethidine Standards
- Pethidine Hydrochloride EP Impurity G (CAS CATO-C4X-22325)
- Pethidine impurity 9 (CAS CATO-C4X-22329)
- Pethidine impurity 6 (CAS CATO-C4X-22326)
- Pethidine impurity 7 (CAS CATO-C4X-22327)
- Pethidine Impurity 5 (CAS 59119-18-5)
- Pethidine EP Impurity D (CAS 28030-27-5)
- 【禁售不询】Pethidine EP Impurity E (CAS 77-17-8)
- Pethidine EP Impurity F (CAS 61886-17-7)
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