Pethidine Impurity N33 CAS 50-13-5
| CAS No. | 50-13-5 |
| Molecular Formula | C15H21NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Pethidine Impurity N33 (CAS 50-13-5), a pharmacopoeial impurity reference standard (molecular formula C15H21NO2HCl, MW 283.80 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Pethidine Impurity N33 (C15H21NO2HCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H21NO2 HCl |
| Molecular Weight | 283.80 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Pethidine Standards
- Pethidine EP Impurity A HCl (CAS 10272-50-1)
- Pethidine Impurity 12 (CAS 13147-07-4)
- Pethidine-d5 Hydrochloride (CAS 1330180-05-6)
- Pethidine Impurity 3 (CAS 158984-76-0)
- Pethidine EP Impurity B HCl (CAS 23007-85-4)
- Pethidine EP Impurity D (CAS 28030-27-5)
- Pethidine EP Impurity B (CAS 28289-54-5)
- Pethidine Impurity 1 (CAS 51281-64-2)
Recommended Standards
- Dapagliflozin impurity N1 (CAS 960494-15-9)
- Ivacaftor impurity 16 (CAS CATO-C4X-296416)
- Enzalutamide Impurity 12 (CAS CATO-C4X-101612)
- tert-butyl 2,2-dimethylpiperazine-1-carboxylate (CAS 674792-07-5)
- Nitazoxanide (CAS 55981-09-4)
- [(R)-BINAP-RuCl(benzene)]Cl (CAS 124069-39-2)
- 1-Methyl-2-phenoxy-1H-indole-3-carbaldehyde (CAS 338416-80-1)
- Methyl 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-3-carboxylate hydrochloride (CAS 2137768-58-0)
- (5,6,7,8-Tetrahydro-4H-cyclohepta[d]isoxazol-3-yl)methanesulfonyl chloride (CAS 2138169-55-6)
- Semaglutide impurity 37 (CAS CATO-C4X-222637)
Why CATO?
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