Clotrimazole Impurity 15 CAS 2136-81-4
| CAS No. | 2136-81-4 |
| Molecular Formula | C7H4Cl4 |
| Molecular Weight | 229.92 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Clotrimazole Impurity 15 is closely related to chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Clotrimazole Impurity 15 (CAS 2136-81-4), a pharmacopoeial impurity reference standard (molecular formula C7H4Cl4, MW 229.92 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C7H4Cl4, Clotrimazole Impurity 15 contains chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 229.92 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Clotrimazole Impurity 15 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H4Cl4 |
| Molecular Weight | 229.92 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
Related Clotrimazole Standards
- Clotrimazole EP Impurity E (CAS 5162-03-8)
- Clotrimazole Impurity 26 (CAS 29921-41-3)
- Clotrimazole Impurity 12 (CAS 15145-69-4)
- Clotrimazole Impurity 25 (CAS 3509-85-1)
- Clotrimazole Impurity 20 (CAS 3005-50-3)
- Clotrimazole Impurity 27 (CAS 56153-60-7)
- Clotrimazole Impurity 1 (CAS 968-39-8)
- Clotrimazole EP Impurity A (CAS 66774-02-5)
Recommended Standards
- Clevidipine Butyrate impurity 27 (CAS 57058-14-7)
- 2-Chlorobenzotrichloride (CAS 2136-89-2)
- 2,4-Dichloro-1-(dichloromethyl)benzene (CAS 134-25-8)
- Alpha,Alpha,Alpha,4-Tetrachlorotoluene (CAS 5216-25-1)
- Apalutamide impurity 85 (CAS CATO-C4X-274985)
- N-Nitroso Valaciclovir Impurity P (CAS CATO-C4X-124852)
- Picosulfate impurity 21 (CAS CATO-C4X-123721)
- 6-Chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one (CAS 247237-58-7)
- Methyl 2,3-diamino-5-chlorobenzoate (CAS 314248-61-8)
- 2-(Isopropyl(1-(thiazol-2-yl)ethyl)amino)acetic acid (CAS 1353947-25-7)
- 5-Amino-1,3,4-thiadiazole-2-carbaldehyde (CAS 29422-54-6)
- 2-(3-Bromopropoxy)acetic acid (CAS 198422-74-1)
- 5-Decylpyrimidine-2,4,6-triamine (CAS 94087-75-9)
- Des-Ile17-Tirzepatide (CAS CATO-CPTD788956)
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