Erlotinib Impurity 112 CAS 99-03-6
| CAS No. | 99-03-6 |
| Molecular Formula | C8H9NO |
| Molecular Weight | 135.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Erlotinib Impurity 112 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Erlotinib Impurity 112 (CAS 99-03-6, C8H9NO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C8H9NO, Erlotinib Impurity 112 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 135.16 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C8H9NO |
| Molecular Weight | 135.16 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Erlotinib Standards
- Erlotinib Impurity 117 (CAS 139-85-5)
- Erlotinib Impurity 106 (CAS 6482-24-2)
- Erlotinib Impurity 24 (CAS 134690-40-7)
- Erlotinib Impurity 113 (CAS 587-02-0)
- Erlotinib Impurity 122 (CAS 1709-44-0)
- Erlotinib Impurity 116 (CAS 15411-43-5)
- Erlotinib Impurity 114 (CAS 14235-81-5)
- Erlotinib Impurity 115 (CAS 52670-38-9)
Recommended Standards
- 1-(pyridin-3-yl)propan-2-one (CAS 6302-03-0)
- Linagliptin Impurity 59 (CAS 551-93-9)
- 1,3-Dimethyl-2-Nitrosobenzene (Mixture of Monomer and Dimer) (CAS 19519-71-2)
- Acetaminophen EP impurity D (CAS 103-84-4)
- Mizolastine Impurity 8 (CAS CATO-C4X-20068)
- Finerenone Impurity 107 (CAS CATO-C4X-2880107)
- Bacampicillin EP Impurity I N,N＇-Dibenzylethylenediamine (CAS 33276-75-4)
- 1-Benzyl-4-(2-chlorophenoxy)piperidine (CAS 900512-07-4)
- 3-(2-Aminophenyl)pentan-3-ol (CAS 15832-98-1)
- 3,5-dichloro-4-hydroxybenzene-1-sulfonyl chloride (CAS 13432-81-0)
- 1-(3-Fluorophenyl)-4-methylpentan-1-amine (CAS 1249221-77-9)
- [(2R,4R)-4-[2-Amino-6-(cyclopropylamino)purin-9-yl]-1,3-dioxolan-2-yl]methanol (CAS 280138-71-8)
- 2-((4-(4-Bromophenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-sulfamoylphenyl)acetamide (CAS 477329-42-3)
- C-Type Natriuretic Peptide (32-53) (human, porcine, rat) (CAS 127869-51-6)
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