Benazepril Hydrochloride EP Impurity G Hydrochloride CAS 103129-58-4
| CAS No. | 103129-58-4 |
| Molecular Formula | C26H32N2O5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Benazepril Hydrochloride EP Impurity G Hydrochloride is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Benazepril Hydrochloride EP Impurity G Hydrochloride (CAS 103129-58-4, C26H32N2O5HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Benazepril Hydrochloride EP Impurity G Hydrochloride (C26H32N2O5HCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Benazepril Hydrochloride EP Impurity G Hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H32N2O5 HCl |
| Molecular Weight | 489.01 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Benazepril Standards
- Benazepril Impurity 2 (CAS 105260-10-4)
- Benazepril EP Impurity F (CAS 109010-60-8)
- Benazepril tert-Butyl Ester (CAS 109010-61-9)
- Benazepril EP Impurity D (CAS 112110-48-2)
- Benazepril-d5 HCl (CAS 1279026-26-4)
- Benazepril-d5 (CAS 1279200-03-1)
- Benazepril EP Impurity A (CAS 131064-75-0)
- Benazepril tert-Butyl Ester-d5 (CAS 1356010-96-2)
Recommended Standards
- Dotinurad Impurity 32 (CAS CATO-C4X-249432)
- Norepinephrine Impurity 11 (CAS CATO-C4X-151411)
- Furosemide Impurity 63 (CAS CATO-C4X-140263)
- 1-Boc-4-(3-Aminobenzyl)piperazine (CAS 361345-40-6)
- 2-Hydroxyethyl Palmitate (CAS 4219-49-2)
- 4-Acetoxy-3,5-dimethoxybenzoic acid (CAS 6318-20-3)
- 2-Methoxy-3-n-propylpyrazine (CAS 25680-57-3)
- 2-phenylcyclopent-1-ene-1-carboxylic acid (CAS 156774-71-9)
- 3-Amino-6-propylpyrazine-2-carbonitrile (CAS 50627-23-1)
- Semaglutide Impurity 151 xTFA (CAS CATO-C4X-2226151)
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