Benazepril EP Impurity A CAS 131064-75-0
| CAS No. | 131064-75-0 |
| Molecular Formula | C24H28N2O5 |
| Molecular Weight | 424.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Benazepril EP Impurity A is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Benazepril EP Impurity A (CAS 131064-75-0, C24H28N2O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, Benazepril EP Impurity A is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 424.49 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H28N2O5 |
| Molecular Weight | 424.49 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Nitrogen Atoms | 2 |
Related Benazepril Standards
- Benazepril EP Impurity B(1R,3S-Isomer) (CAS 86541-76-6)
- Benazepril Impurity B (CAS 98626-50-7)
- Benazepril (CAS 86541-75-5)
- Benazepril-d5 (CAS 1279200-03-1)
- Benazepril EP Impurity D (CAS 112110-48-2)
- Benazepril EP Impurity C (CAS 86541-78-8)
- Benazepril Impurity 13 (CAS CATO-C4X-209613)
- Benazepril tert-Butyl Ester (CAS 109010-61-9)
Recommended Standards
- 2-((R)-3-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetic Acid (CAS 131064-74-9)
- Bisindolylmaleimide X, 98% (CAS 131848-97-0)
- Cathayanon H (CAS 1303438-51-8)
- 8-Benzyl-4-[2-(4-methoxyphenyl)acetyl]-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (CAS 1326810-24-5)
- Lumateperone Impurity 67 (CAS CATO-C4X-220167)
- Allisartan Isoproxil Impurity 3 (CAS CATO-C4X-32173)
- Vonoprazan Impurity 238 (CAS 1831110-76-9)
- Lauric Acid-N-Butyl Ester (CAS 106-18-3)
- 2-Ethynyl-1H-imidazole (CAS 57121-47-8)
- 10-Hydroxy Protriptyline (CAS 27462-57-3)
- rel-(2R,3S)-3-aminooxetane-2-carboxylic acid (CAS 198563-29-0)
- Sunitinib Impurity 61 (CAS CATO-C4X-133361)
- n-(2,6-Dimethylphenyl)-2-((4-phenyl-5-(pyridin-4-yl)-4h-1,2,4-triazol-3-yl)thio)acetamide (CAS 337505-62-1)
- Semaglutide impurity 55 (CAS CATO-C4X-222655)
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