2-(Trifluoromethyl)pyrimidine-5-carbonitrile CAS 1032229-36-9

Purity 97%+In StockPharmaceutical Standards
CAS No.1032229-36-9
Molecular FormulaC6H2F3N3
Molecular Weight173.10 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

2-(Trifluoromethyl)pyrimidine-5-carbonitrile CAS 1032229-36-9 chemical structure

Description

The occurrence of 2-(Trifluoromethyl)pyrimidine-5-carbonitrile is closely related to a nitrile group, fluorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

2-(Trifluoromethyl)pyrimidine-5-carbonitrile (CAS 1032229-36-9) is a high-purity analytical reference standard with the molecular formula C6H2F3N3 and a molecular weight of 173.10 g/mol.

The molecular framework of 2-(Trifluoromethyl)pyrimidine-5-carbonitrile (C6H2F3N3) is characterized by a nitrile group, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 2-(Trifluoromethyl)pyrimidine-5-carbonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC6H2F3N3
Molecular Weight173.10 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)6.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1988
Halogen ContentF-containing
Nitrogen Atoms3

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