5-(Trifluoromethyl)pyrazine-2-carbonitrile CAS 1279818-65-3
| CAS No. | 1279818-65-3 |
| Molecular Formula | C6H2F3N3 |
| Molecular Weight | 173.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 5-(Trifluoromethyl)pyrazine-2-carbonitrile (C6H2F3N3) is characterized by a nitrile group, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
5-(Trifluoromethyl)pyrazine-2-carbonitrile (CAS 1279818-65-3) is a high-purity analytical reference standard with the molecular formula C6H2F3N3 and a molecular weight of 173.10 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 5-(Trifluoromethyl)pyrazine-2-carbonitrile under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C6H2F3N3 |
| Molecular Weight | 173.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Trifluoromethyl Standards
- 2-(Trifluoromethyl)pyrimidine-5-carbonitrile (CAS 1032229-36-9)
- 4-(Trifluoromethyl)pyrimidine-2-carbonitrile (CAS 1206459-86-0)
- 6-(Trifluoromethyl)pyridazine-3-carbonitrile (CAS 1206524-27-7)
- 4-(Trifluoromethyl)pyrimidine-5-carbonitrile (CAS 1260676-79-6)
- 6-(Trifluoromethyl)pyrimidine-4-carbonitrile (CAS 1359996-77-2)
- 2-(Trifluoromethyl)pyrimidine-4-carbonitrile (CAS 916210-03-2)
- 5-(Trifluoromethyl)pyrimidine-2-carbonitrile (CAS 944905-38-8)
- o-(Trifluoromethyl)-d-serine (CAS 1286761-84-9)
Recommended Standards
- (3-Aminopropyl)(difluoromethyl)phosphinic acid (CAS 133345-73-0)
- 5-Fluoro-2-nitrobenzene-1,3-diol (CAS 1121585-22-5)
- 4,6,7-Trifluoro-1H-imidazo[4,5-c]pyridine (CAS 405230-95-7)
- 2-Amino-4,4,4-trifluoro-3-hydroxybutanoic acid (CAS 434-38-8)
- VA-012 (CAS 885898-58-8)
- 4-Amino-7-bromopyrrolo[2,1-f][1,2,4]triazine-5-carbonitrile (CAS 1909271-53-9)
- 3-Phenyldibenzothiophene (CAS 98251-30-0)
- 3-(Benzo[d]oxazol-2-yl)-4-fluoroaniline (CAS 220705-28-2)
- 2,6-Diphenylpyridin-3-amine (CAS 56568-39-9)
- Tert-butyl (1R,4R,5R)-5-amino-2-azabicyclo[2.2.2]Octane-2-carboxylate (CAS 1932338-50-5)
- 2-(3-Bromophenyl)-5-(tert-pentyl)oxazole (CAS 1351386-33-8)
- (4-((2,5-Dimethylphenyl)carbamoyl)phenyl)boronic acid (CAS 913835-40-2)
- 3-Chloro-4-fluorophenol (CAS 2613-23-2)
- Semaglutide impurity 290 (CAS CATO-C4X-2226290)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com