5-((4-Amino-2-fluorophenyl)amino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione CAS 1035556-26-3
| CAS No. | 1035556-26-3 |
| Molecular Formula | C14H12FN5O2 |
| Molecular Weight | 301.28 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-((4-Amino-2-fluorophenyl)amino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione.
5-((4-Amino-2-fluorophenyl)amino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione (CAS 1035556-26-3), molecular formula C14H12FN5O2 and molecular weight 301.28 g/mol, is a CATO reference standard with documented purity and traceability.
5-((4-Amino-2-fluorophenyl)amino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione (C14H12FN5O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H12FN5O2 |
| Molecular Weight | 301.28 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Amino Standards
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Recommended Standards
- N-{[3-(trifluoromethoxy)phenyl]methyl}thiophene-2-carboxamide (CAS 1024174-11-5)
- N-(5-(1,3-Dimethyl-1H-pyrazol-5-yl)-1,3,4-oxadiazol-2-yl)-3-fluorobenzamide (CAS 1170049-33-8)
- 2-(((5-Nitrothiazol-2-yl)amino)methylene)-1H-indene-1,3(2H)-dione (CAS 1023524-08-4)
- 2-(4-Fluorophenyl)-N-(5-(1-methyl-1H-pyrazol-5-yl)-1,3,4-oxadiazol-2-yl)acetamide (CAS 1171184-71-6)
- 2-Oxo-2-(pyridin-3-yl)acetaldehyde (CAS 63464-84-6)
- n-(9-((6Ar,8r,9r,9as)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6h-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-9h-purin-6-yl)benzamide (CAS 79154-57-7)
- 2-fluoro-4-nitrobenzene-1-sulfonyl chloride (CAS 1146290-36-9)
- N1,N1'-(1,3-phenylene)bis(2-chloro-N1,N3,N3-triphenylbenzene-1,3-diamine) (CAS 1800321-80-5)
- 4-Amino-6-cyano-5-(trifluoromethoxy)pyridine-3-sulfonyl chloride (CAS 1804026-59-2)
- 5-Chloropyridine-2,4-diol (CAS 1253661-61-8)
- Quetiapine EP Impurity D (CAS 945668-94-0)
- (2,6-Dibromopyridin-3-yl)boronic acid (CAS 1256355-52-8)
- N-[(2-{imidazo[1,2-a]pyridin-2-ylmethoxy}phenyl)methylidene]hydroxylamine (CAS 1235441-84-5)
- Semaglutide Impurity 155 (x TFA Salt) (CAS CATO-C4X-2226155)
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