Domperidone Impurity 18 CAS 103784-04-9
| CAS No. | 103784-04-9 |
| Molecular Formula | C10H11BrN2O |
| Molecular Weight | 255.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Domperidone Impurity 18 (C10H11BrN2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 255.11 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO supplies Domperidone Impurity 18 (CAS 103784-04-9), a pharmacopoeial impurity reference standard (molecular formula C10H11BrN2O, MW 255.11 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H11BrN2O |
| Molecular Weight | 255.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Domperidone Standards
- Domperidone EP Impurity A (CAS 53786-28-0)
- Domperidone Impurity 14 (CAS 62780-84-1)
- Domperidone Impurity 13 (CAS 87120-77-2)
- Domperidone Impurity 35 (CAS CATO-C4X-142035)
- Domperidone Impurity 15 (CAS 13733-33-0)
- Domperidone Impurity 16 (CAS 24731-73-5)
- Domperidone EP Impurity B (CAS 1346598-11-5)
- Domperidone Impurity 29 (CAS CATO-C4X-142029)
Recommended Standards
- 951887-62-0 2-Bromo-3-[(3,4-ethylenedioxy)phenyl]-1-propene MFCD07782401 (CAS 951887-62-0)
- Ozagrel Impurity 33 (CAS 946-99-6)
- 74519-39-4 A838157 N-(4-methylphenyl)-2-oxidanylidene-propanehydrazonoyl bromide N-(4-methylphenyl)-2-oxopropanehydrazonoyl bromide (CAS 74519-39-4)
- 2-((3,5-Dichlorophenyl)sulfonyl)ethan-1-ol (CAS 101079-90-7)
- Cabazitaxel Impurity 26 (CAS 144790-01-2)
- Lasmiditan Impurity 9 (CAS 498-94-2)
- Oseltamivir Impurity 18 (CAS 941296-96-4（free base）)
- 4-Methoxy-3-nitropyridine hydrate (CAS 1881293-28-2)
- 1-(2-(4-Nitrophenyl)-2-oxoethyl)pyridin-1-ium iodide (CAS 5330-73-4)
- 3-(2,2-Dimethoxyethyl)-5-(methylthio)-4-(3-(trifluoromethyl)phenyl)-4H-1,2,4-triazole (CAS 320424-71-3)
- 2-Methylpyrimidine-5-boronic Acid (CAS 1034924-06-5)
- 2-((2,4-Dimethylphenyl)thio)-N-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)acetamide (CAS 478260-47-8)
- N-(2-hydroxyethyl)benzenesulfonamide (CAS 59724-42-4)
- Endo-Gly4-Semaglutide (CAS CATO-C4X-222679)
Why CATO?
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