Domperidone EP Impurity A CAS 53786-28-0
| CAS No. | 53786-28-0 |
| Molecular Formula | C12H14ClN3O |
| Molecular Weight | 251.71 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Domperidone EP Impurity A (CAS 53786-28-0, C12H14ClN3O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Domperidone EP Impurity A (C12H14ClN3O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 251.71 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Domperidone EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H14ClN3O |
| Molecular Weight | 251.71 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Domperidone Standards
- Domperidone Impurity 14 (CAS 62780-84-1)
- Domperidone Impurity 18 (CAS 103784-04-9)
- Domperidone Impurity 13 (CAS 87120-77-2)
- Domperidone Impurity 35 (CAS CATO-C4X-142035)
- Domperidone Impurity 15 (CAS 13733-33-0)
- Domperidone Impurity 16 (CAS 24731-73-5)
- Domperidone Impurity 30 (CAS 62780-76-1)
- Domperidone EP Impurity B (CAS 1346598-11-5)
Recommended Standards
- Brexpiprazole Impurity 7 (CAS 913613-82-8)
- Lornoxicam Impurity 31 (CAS CATO-C4X-201631)
- Brexpiprazole Impurity 24 (CAS 2809183-06-8)
- Pyrimethamine EP Impurity D (CAS 55474-41-4)
- Cabergoline EP Impurity B (CAS 166533-36-4)
- Axitinib Impurity 86 (CAS 1824099-80-0)
- iotropium Bromide Impurity 12 (CAS 588-63-6)
- 1-(Pyridin-4-yl)propan-2-amine (CAS 801173-51-3)
- 1-(4-Fluorobenzyl)-4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one (CAS 912890-38-1)
- tert-Butyl 2-(4-iodophenyl)acetate (CAS 856250-87-8)
- (1R)-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (CAS 1389890-72-5)
- 2-(4-Bromothiophen-2-yl)-2-(morpholin-4-yl)acetic acid hydrochloride (CAS 1354949-60-2)
- (2,4,6-Trimethylpyrimidin-5-yl)boronic acid (CAS 1469931-07-4)
- Hexapeptide-11 (CAS 161258-30-6)
Why CATO?
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