Triamcinolone Acetonide EP Impurity D CAS 10392-74-2
| CAS No. | 10392-74-2 |
| Molecular Formula | C24H31ClO6 |
| Molecular Weight | 450.95 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Triamcinolone Acetonide EP Impurity D is closely related to a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Triamcinolone Acetonide EP Impurity D (CAS 10392-74-2) is a certified pharmaceutical impurity reference standard with the molecular formula C24H31ClO6 and a molecular weight of 450.95 g/mol.
The molecular framework of Triamcinolone Acetonide EP Impurity D (C24H31ClO6) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Triamcinolone Acetonide EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H31ClO6 |
| Molecular Weight | 450.95 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1959 |
| Halogen Content | Cl-containing |
Related Triamcinolone Standards
- Triamcinolone Acetonide EP Impurity C (CAS 161740-69-8)
- Triamcinolone Impurity 40 (CAS CATO-C4X-132640)
- Triamcinolone Acetonide Impurity 49 (CAS 7704-77-0)
- Triamcinolone Acetonide Impurity 38 (CAS CATO-C4X-132638)
- Triamcinolone Acetonide Impurity 44 (CAS CATO-C4X-132644)
- Triamcinolone Acetonide Impurity 48 (CAS 1418196-53-8)
- Triamcinolone Acetonide Impurity 46 (CAS CATO-C4X-132646)
- Triamcinolone Acetonide-d6 (CAS 352431-33-5)
Recommended Standards
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- Flecainide Impurity 12 (CAS CATO-C4X-254612)
- Ozanimod Impurity 14 (CAS CATO-C4X-290214)
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