Betamethasone impurity 66 CAS 4735-64-2
| CAS No. | 4735-64-2 |
| Molecular Formula | C24H31ClO6 |
| Molecular Weight | 450.95 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Betamethasone impurity 66 (CAS 4735-64-2), a pharmacopoeial impurity reference standard (molecular formula C24H31ClO6, MW 450.95 g/mol) used for the identification and quantification of trace impurities in APIs.
Betamethasone impurity 66 (C24H31ClO6) contains a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H31ClO6 |
| Molecular Weight | 450.95 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
Related Betamethasone Standards
- Betamethasone Impurity 108 (CAS CATO-C4X-1437108)
- Betamethasone impurity 114 (CAS 72559-76-3)
- Betamethasone Impurity 111 (CAS CATO-C4X-1437111)
- Betamethasone Impurity 143 (CAS CATO-C4X-1437143)
- Betamethasone Impurity 28 (CAS CATO-C4X-143728)
- Betamethasone impurity 48 (CAS CATO-C4X-143748)
- Betamethasone Impurity 42 (CAS 25122-45-6)
- Betamethasone impurity 106 (CAS 330157-03-4)
Recommended Standards
- Triamcinolone Acetonide EP Impurity D (CAS 10392-74-2)
- Mometasone Furoate EP Impurity O (CAS 24916-91-4)
- Empagliflozin Impurity 101 (CAS CATO-C4X-1065101)
- Halcinonide Impurity 13 (CAS CATO-C4X-279513)
- Imidapril Impurity 13 (CAS 157085-03-5(free base))
- Rivaroxaban Impurity 87 (CAS CATO-C4X-109087)
- Vortioxetine Impurity 2 (CAS 1011-13-8)
- 3-Bromo-5-cyano-4-nitrobenzoic acid (CAS 1805572-26-2)
- Ethyl 5,5,5-trifluoro-4-hydroxypentanoate (CAS 70961-06-7)
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- 2-Amino-5-bromo-3-chloropyridine (CAS 38185-55-6)
- Insulin B (22-25) (CAS 34367-73-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com