Tiotropium Bromide EP Impurity H (Mixture of Enantiomers) CAS 1044148-31-3
| CAS No. | 1044148-31-3 |
| Molecular Formula | C9H16NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Tiotropium Bromide EP Impurity H (Mixture of Enantiomers) (CAS 1044148-31-3, C9H16NO2Br) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, Tiotropium Bromide EP Impurity H (Mixture of Enantiomers) is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 250.14 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO manufactures Tiotropium Bromide EP Impurity H (Mixture of Enantiomers) under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C9H16NO2 Br |
| Molecular Weight | 250.14 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Tiotropium Standards
- Tiotropium Impurity 26 (CAS 10299-90-8)
- Tiotropium Bromide Impurity 8 Potassium Salt (CAS 10304-09-3)
- Tiotropium Bromide EP Impurity H-d3 Bromide (Mixture of Enantiomers) (CAS 1044148-31-3（unlabeled）)
- Tiotropium-d6 (CAS 1126775-44-7)
- Tiotropium-D3 Bromide (CAS 1127226-56-5)
- Tiotropium Bromide EP Impurity B (CAS 136310-64-0)
- Tiotropium EP Impurity D (CAS 136310-66-2)
- Tiotropium Bromide (CAS 136310-93-5)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com