1-(4-Chlorophenyl)-5-[(E)-[(4-fluorophenyl)methylidene]amino]-6-imino-2-oxo-1,2,3,6-tetrahydropyrimidine-4-carbonitrile CAS 1048915-26-9
| CAS No. | 1048915-26-9 |
| Molecular Formula | C18H11ClFN5O |
| Molecular Weight | 367.76 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-(4-Chlorophenyl)-5-[(E)-[(4-fluorophenyl)methylidene]amino]-6-imino-2-oxo-1,2,3,6-tetrahydropyrimidine-4-carbonitrile (CAS 1048915-26-9), molecular formula C18H11ClFN5O and molecular weight 367.76 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1-(4-Chlorophenyl)-5-[(E)-[(4-fluorophenyl)methylidene]amino]-6-imino-2-oxo-1,2,3,6-tetrahydropyrimidine-4-carbonitrile (C18H11ClFN5O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 1-(4-Chlorophenyl)-5-[(E)-[(4-fluorophenyl)methylidene]amino]-6-imino-2-oxo-1,2,3,6-tetrahydropyrimidine-4-carbonitrile under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H11ClFN5O |
| Molecular Weight | 367.76 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Chlorophenyl Standards
- 6-(4-chlorophenyl)-1-(2-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid (CAS 1011397-66-2)
- 2-[(4-Chlorophenyl)amino]-4-(4-nitrophenyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile (CAS 1348555-04-3)
- 4-(2-Chlorophenyl)-5-methyl-2-(3-(trifluoromethyl)benzyl)-2,4-dihydro-3H-1,2,4-triazol-3-one (CAS 861205-97-2)
- 4-(3-Chlorophenyl)-3-methyl-1-{[3-(trifluoromethyl)phenyl]methyl}-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 860786-42-1)
- 4-(4-Chlorophenyl)-3-methyl-1-{[3-(trifluoromethyl)phenyl]methyl}-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 860786-62-5)
- 6-(2-Chlorophenyl)-2-morpholino-4-(trifluoromethyl)nicotinonitrile (CAS 478049-43-3)
- 6-(4-Chlorophenyl)-2-morpholino-4-(trifluoromethyl)nicotinonitrile (CAS 338749-81-8)
- 4-[(4-Chlorophenyl)sulfanyl]-2-(pyridin-2-yl)-6-(trifluoromethyl)pyrimidine (CAS 338418-08-9)
Recommended Standards
- 5-[(E)-[(2-Chloro-6-fluorophenyl)methylidene]amino]-6-imino-2-oxo-1-phenyl-1,2,3,6-tetrahydropyrimidine-4-carbonitrile (CAS 1159976-68-7)
- n-(2-Chlorobenzyl)-2-(2-(trifluoromethyl)-1h-benzo[d]imidazol-1-yl)acetamide (CAS 478048-07-6)
- Dinitrato(1,10-phenanthroline)copper(II) (CAS 19319-88-1)
- 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-propyl-1H-pyrrole-2-sulfonamide (CAS 321433-68-5)
- Annomuricin B (CAS 167355-37-5)
- (E)-[1-(4-Methyl-2-phenyl-1,3-thiazol-5-yl)ethylidene]amino N-ethylcarbamate (CAS 477858-16-5)
- Tert-butyl 6-(hydroxymethyl)-1,3-dihydro-2H-pyrrolo[3,4-c]pyridine-2-carboxylate (CAS 2065165-84-4)
- 1-(Prop-2-ynyl)-1H-pyrido[2,3-d][1,3]oxazine-2,4-dione (CAS 97484-76-9)
- 3-Bromo-1-(4-chloro-2-fluorophenyl)pyrrolidin-2-one (CAS 1342993-07-0)
- 3-Bromo-4,5-diethoxy-benzylamine hydrochloride (CAS 1052510-28-7)
- 2-((4-(4-Bromophenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(m-tolyl)acetamide (CAS 477330-36-2)
- 9-Methyl-1H-isochromeno[6',5',4':10,5,6]anthra[2,1,9-def]isoquinoline-1,3,8,10(9H)-tetraone (CAS 70654-96-5)
- (2-(3,5-Dimethyl-1H-pyrazol-1-yl)-5-methoxyphenyl)methanol (CAS 918812-46-1)
- Insulin degludec (CAS 844439-96-9)
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