Hydroxychloroquine EP Impurity E CAS 10500-64-8
| CAS No. | 10500-64-8 |
| Molecular Formula | C14H17ClN2O |
| Molecular Weight | 264.75 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 264.75 g/mol gives Hydroxychloroquine EP Impurity E distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Hydroxychloroquine EP Impurity E (CAS 10500-64-8) is a certified pharmaceutical impurity reference standard with the molecular formula C14H17ClN2O and a molecular weight of 264.75 g/mol.
Based on its molecular formula C14H17ClN2O, Hydroxychloroquine EP Impurity E contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 264.75 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H17ClN2O |
| Molecular Weight | 264.75 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1960 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Hydroxychloroquine Standards
- Hydroxychloroquine Impurity 75 (CAS 100713-49-3)
- Hydroxychloroquine RC 2 (CAS 860715-45-3)
- Hydroxychloroquine impurity 84 (CAS CATO-C4X-183584)
- Hydroxychloroquine Impurity 70 (CAS 56881-09-5)
- Hydroxychloroquine Impurity 28 (CAS CATO-C4X-183528)
- Hydroxychloroquine impurity 62 (CAS CATO-C4X-183562)
- Hydroxychloroquine impurity 83 (CAS CATO-C4X-183583)
- Hydroxychloroquine EP Impurity F (CAS 6281-58-9)
Recommended Standards
- Loxoprofen Impurity 56 (CAS 200554-09-2)
- Hexachloroacetone (CAS 116-16-5)
- 2-Chloro-N-(2,3-dihydro-1,3,3-trimethyl-2-methylene-1H-indol-5-yl)acetamide 5-Chloroacetamido-2-methylene-1,3,3-trimethylindoline 51980-53-1 (CAS 51980-53-1)
- 4-Chloro-p-terphenyl (CAS 1762-83-0)
- Cinitapride Impurity 15 (CAS CATO-C4X-290815)
- Rabeprazole impurity 46 (CAS CATO-C4X-112146)
- Ritonavir Impurity N11 (CAS 2519851-81-9)
- 4-(4-Methyl-5-(methylthio)-4H-1,2,4-triazol-3-yl)-2-(3-(trifluoromethyl)phenyl)thiazole (CAS 400083-71-8)
- 157124-41-9 4-(5-Methyl-1H-tetrazol-1-yl)phenol 4943AD C8H8N4O (CAS 157124-41-9)
- 5-Methyl-1,3,4-thiadiazole-2-sulfonyl chloride (CAS 184222-90-0)
- 4-(4-Cyano-5-(trifluoromethyl)-1H-pyrazol-1-yl)benzoic acid (CAS 956742-33-9)
- Methyl 2-(2h-1,2,3,4-tetrazol-5-yl)acetate (CAS 26476-32-4)
- Lopinavir EP Impurity S (CAS 943250-65-5)
- Q-Peptide trifluoroacetate salt (CAS 1361235-89-3)
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