Cobicistat impurity 12 CAS 1051463-40-1
| CAS No. | 1051463-40-1 |
| Molecular Formula | C40H53N7O6S2 |
| Molecular Weight | 792.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Cobicistat impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Cobicistat impurity 12 (CAS 1051463-40-1) is a certified pharmaceutical impurity reference standard with the molecular formula C40H53N7O6S2 and a molecular weight of 792.02 g/mol.
Cobicistat impurity 12 (C40H53N7O6S2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C40H53N7O6S2 |
| Molecular Weight | 792.02 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 7 |
| Sulfur Atoms | 2 |
Related Cobicistat Standards
- Cobicistat impurity 13 (CAS 2984891-98-5)
- Cobicistat-d8 (CAS CATO-C4X-18162)
- Cobicistat (CAS 1004316-88-4)
- Cobicistat Impurity 3 (CAS 1051463-82-1)
- Cobicistat Impurity 4 (CAS 2230789-82-7)
- Cobicistat Impurity 5 (CAS 2230789-57-6)
- Cobicistat impurity 15 (CAS CATO-C4X-181615)
- Cobicistat impurity 14 (CAS 1051463-15-0)
Recommended Standards
- 2′-(3-Dodecylphenyl)-1′,5′-dihydro-1′-methyl-2′H-[5,6]fullereno-C60-Ih-[1,9-c]pyrrole (CAS 403483-19-2)
- Tulathromycin A Impurity 5 (CAS 2051579-12-3)
- Isomers of Ascomycin (CAS CATO-C4X-20742)
- Fmoc-Lys(palmitoyl-Glu-OtBu)-OH (CAS 1491158-62-3)
- Bisoprolol Impurity 22 (CAS 1447715-45-8)
- Nilotinib Impurity 42 (CAS CATO-C4X-125642)
- Linezolid Impurity 31 (CAS CATO-C4X-107331)
- 1-(2,4-Dibromophenyl)-1h-pyrazole-3-carboxylic acid (CAS 1248750-82-4)
- 5-Methoxy-1-methyl-3,4-dihydronaphthalen-2(1H)-one (CAS 42263-75-2)
- 1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]-1,4-diazepane dihydrochloride (CAS 1311318-24-7)
- 3-(1H-imidazol-5-yl)propanoic acid;hydrochloride (CAS 53958-93-3)
- (R)-1,2,3,4-Tetrahydronaphthalen-2-ol (CAS 7575-89-5)
- 3-Phenyl-5-(trifluoromethyl)picolinonitrile (CAS 1214335-58-6)
- Peptide 438 (CAS CATO-CPTD788438)
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