Cobicistat Impurity 3 CAS 1051463-82-1
| CAS No. | 1051463-82-1 |
| Molecular Formula | C40H53N7O5S2 |
| Molecular Weight | 776.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Cobicistat Impurity 3 (CAS 1051463-82-1, C40H53N7O5S2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C40H53N7O5S2, Cobicistat Impurity 3 contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 776.02 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C40H53N7O5S2 |
| Molecular Weight | 776.02 g/mol |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 7 |
| Sulfur Atoms | 2 |
Related Cobicistat Standards
- Cobicistat (CAS 1004316-88-4)
- Cobicistat Impurity 4 (CAS 2230789-82-7)
- Cobicistat Impurity 5 (CAS 2230789-57-6)
- Cobicistat-d8 (CAS CATO-C4X-18162)
- Cobicistat impurity 13 (CAS 2984891-98-5)
- Cobicistat impurity 12 (CAS 1051463-40-1)
- Cobicistat impurity 14 (CAS 1051463-15-0)
- Cobicistat impurity 15 (CAS CATO-C4X-181615)
Recommended Standards
- Pimecrolimus Impurity 22 (CAS 137712-89-1)
- Tacrolimus impurity 48 (CAS CATO-C4X-130048)
- Iohexol impurity 47 (CAS CATO-C4X-166447)
- Tacrolimus Impurity 31 (CAS 123719-19-7)
- Citalopram Impurity 21 (CAS 1433278-32-0)
- Doxycycline Impurity 25 (CAS CATO-C4X-193125)
- Ritonavir EP Impurity R (CAS 1414933-80-4)
- (6,7-Dimethyl-1H-benzo[d]imidazol-2-yl)methanol (CAS 915921-59-4)
- 4-Amino-6-(quinolin-6-yloxy)pyrimidine-5-carbaldehyde (CAS 919485-87-3)
- 4-((1-Methyl-2,4-dioxo-6-(3-phenylprop-1-yn-1-yl)-1,2-dihydroquinazolin-3(4H)-yl)methyl)benzoic acid (CAS 451471-51-5)
- N-(2-(5-(2-Fluorophenyl)-1-(thiophene-2-carbonyl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)methanesulfonamide (CAS 923194-63-2)
- 2-Isobutoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS 1357397-80-8)
- N2-Nitroso Abrocitinib (CAS CATO-C4X-28846)
- Semaglutide impurity 29 (CAS 110990-08-4)
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